Detailed information of TA system TA108828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 966926..967729
• Replicon: chromosome
• Accession: NZ_CP031280
• Organism: Staphylococcus pasteuri strain 3C

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: DWB95_RS04755
• Protein ID: WP_126567444.1
• Coordinates: 967553..967729 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A654BAN2
• Locus tag: DWB95_RS04750
• Protein ID: WP_017638029.1
• Coordinates: 966926..967525 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB95_RS04730	962825..964285	+	1461	WP_154874278.1	ABC transporter substrate-binding protein/permease	-
DWB95_RS04735	964278..965000	+	723	WP_046466853.1	amino acid ABC transporter ATP-binding protein	-
DWB95_RS04740	965143..966273	+	1131	WP_046466852.1	tRNA epoxyqueuosine(34) reductase QueG	-
DWB95_RS04745	966274..966744	+	471	WP_017638028.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DWB95_RS04750	966926..967525	+	600	WP_017638029.1	glucosamine-6-phosphate isomerase	Antitoxin
DWB95_RS04755	967553..967729	+	177	WP_126567444.1	hypothetical protein	Toxin
DWB95_RS04760	967881..968273	+	393	WP_017638031.1	hypothetical protein	-
DWB95_RS04765	968429..969814	+	1386	WP_154874281.1	class II fumarate hydratase	-
DWB95_RS04770	969874..970704	-	831	WP_154874283.1	RluA family pseudouridine synthase	-
DWB95_RS04775	970882..971994	+	1113	WP_126567446.1	GAF domain-containing sensor histidine kinase	-
DWB95_RS04780	972015..972638	+	624	WP_126567447.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6799.17 Da
• Isoelectric Point: 3.8537

>T108828 WP_126567444.1 NZ_CP031280:967553-967729 [Staphylococcus pasteuri]
MIQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSDVRSDLEE

Nucleotide

• Length: 177 bp

>T108828 NZ_CP031280:967553-967729 [Staphylococcus pasteuri]
ATGATACAAAATAAAGATTCTAAAACTAATTATCATGAAGAAGAAAATGCTATGGTAACTGATTTAGATGATTTAAAAGA
TTTAGGTAAAGAAATGGAACAAATTTCTGAGGAAAATGATGAAGATAAATTAAACCAATCACATGATTCAGATGTTCGTT
CTGATTTAGAAGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22646.58 Da
• Isoelectric Point: 4.9933

>AT108828 WP_017638029.1 NZ_CP031280:966926-967525 [Staphylococcus pasteuri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVELHAVDFSQINILDYDENKSYYEALGV
PQSQIYSLSYNQDANEFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT108828 NZ_CP031280:966926-967525 [Staphylococcus pasteuri]
ATGGCAATGAACTTTAAAGTATTCGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAGTTTAA
CAACAATCCTATGACTATCGCTGGTGTTCACTTAACTAAAGACCATGCACCTGTATTAGATGAACTTAAAAAGAACGTTG
AGTTACATGCAGTTGATTTTAGTCAAATTAACATTTTAGATTATGATGAAAATAAATCATACTATGAAGCTTTAGGCGTA
CCTCAAAGCCAAATTTATTCATTATCTTATAATCAAGATGCTAATGAATTTATTTCTGATAAAATTAAAACAAAAGAAAA
TAAAGGTAAATTAGTGTTACAAGTAGTTTCTATTGATGAGAATGGCAACCTTGATGTAAGCGTAAGACAAGGATTATTAG
AAGCGCGTGAAATTTTCTTAGTTGTTACTGGTAGCAATAAACGCGAAGTAGTTGAAAAATTATATAATGAAAATGGTAAG
TCTAATTATGAACCAGCAGATTTAAAAGCTCATCGCATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGATGTTAAAGAATACTTCACTGCTCGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A654BAN2