Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820315..820844 Replicon chromosome
Accession NZ_CP031280
Organism Staphylococcus pasteuri strain 3C

Toxin (Protein)


Gene name mazF Uniprot ID A0A654BHV4
Locus tag DWB95_RS03920 Protein ID WP_017637331.1
Coordinates 820482..820844 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag DWB95_RS03915 Protein ID WP_002451626.1
Coordinates 820315..820485 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB95_RS03890 816131..816646 + 516 WP_154874225.1 PH domain-containing protein -
DWB95_RS03895 816598..818130 + 1533 WP_154874227.1 PH domain-containing protein -
DWB95_RS03900 818117..818611 + 495 WP_046466913.1 PH domain-containing protein -
DWB95_RS03905 818649..819026 + 378 WP_046466914.1 holo-ACP synthase -
DWB95_RS03910 819075..820223 + 1149 WP_046466915.1 alanine racemase -
DWB95_RS03915 820315..820485 + 171 WP_002451626.1 hypothetical protein Antitoxin
DWB95_RS03920 820482..820844 + 363 WP_017637331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB95_RS03925 821168..822169 + 1002 WP_017637330.1 PP2C family protein-serine/threonine phosphatase -
DWB95_RS03930 822264..822590 + 327 WP_029056199.1 anti-sigma factor antagonist -
DWB95_RS03935 822592..823071 + 480 WP_017637328.1 anti-sigma B factor RsbW -
DWB95_RS03940 823046..823816 + 771 WP_029056200.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13586.75 Da        Isoelectric Point: 9.9783

>T108827 WP_017637331.1 NZ_CP031280:820482-820844 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSENKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T108827 NZ_CP031280:820482-820844 [Staphylococcus pasteuri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGT
TATTATTCAAAATGACACAGGTAATAAATATAGTCCAACAGTAATTGTTGCAGCAATTACTGGAAGGATTAACAAAGCTA
AGATACCCACACATGTAGAAATAGAAAAGAAGAAGTATAAACTTGATAAAGATTCTGTAATCTTACTTGAACAAATTCGA
ACGTTAGATAAAAATCGTTTGAAAGAAAAGCTCACATATTTGTCAGAAAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGTTTACATAATTTTAATCATCCAAAGACTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT108827 WP_002451626.1 NZ_CP031280:820315-820485 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT108827 NZ_CP031280:820315-820485 [Staphylococcus pasteuri]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCAATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BHV4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References