Detailed information of TA system TA108826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809167..809677
• Replicon: chromosome
• Accession: NZ_CP031280
• Organism: Staphylococcus pasteuri strain 3C

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: DWB95_RS03860
• Protein ID: WP_176745287.1
• Coordinates: 809528..809677 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A654BGA3
• Locus tag: DWB95_RS03855
• Protein ID: WP_017636753.1
• Coordinates: 809167..809460 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB95_RS03830	804320..805111	+	792	WP_046466905.1	hydroxyethylthiazole kinase	-
DWB95_RS03835	805112..805753	+	642	WP_046466906.1	thiamine phosphate synthase	-
DWB95_RS03840	805842..806711	+	870	WP_017636756.1	membrane protein insertase YidC	-
DWB95_RS03845	806750..807394	-	645	WP_017636755.1	HD domain-containing protein	-
DWB95_RS03850	807494..808978	-	1485	WP_029056189.1	cardiolipin synthase	-
DWB95_RS03855	809167..809460	+	294	WP_017636753.1	copper-sensing transcriptional repressor CsoR	Antitoxin
DWB95_RS03860	809528..809677	+	150	WP_176745287.1	heavy-metal-associated domain-containing protein	Toxin
DWB95_RS03865	809815..809952	+	138	WP_017636751.1	hypothetical protein	-
DWB95_RS03870	810086..811276	-	1191	WP_017636750.1	rod shape-determining protein RodA	-
DWB95_RS03875	811648..812718	+	1071	WP_029056190.1	D-alanine--D-alanine ligase	-
DWB95_RS03880	812734..814095	+	1362	WP_154874223.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (2-47)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5538.24 Da
• Isoelectric Point: 3.9915

>T108826 WP_176745287.1 NZ_CP031280:809528-809677 [Staphylococcus pasteuri]
METILKEMIGVYDANVDLSNGHISVEFETPANLNSIEKEIYDSGFKVLY

Nucleotide

• Length: 150 bp

>T108826 NZ_CP031280:809528-809677 [Staphylococcus pasteuri]
ATGGAAACAATATTAAAGGAAATGATAGGTGTATATGATGCAAATGTAGATTTAAGCAATGGTCACATTTCAGTTGAATT
TGAGACACCTGCTAATTTAAATAGTATCGAAAAAGAAATTTATGATTCTGGATTTAAAGTGCTTTATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11231.74 Da
• Isoelectric Point: 6.3270

>AT108826 WP_017636753.1 NZ_CP031280:809167-809460 [Staphylococcus pasteuri]
VTEQDHAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCITEKVNNGHQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT108826 NZ_CP031280:809167-809460 [Staphylococcus pasteuri]
GTGACAGAACAAGATCATGCACATCACTCAGAACAAATTAAAACAAATTTGAAATCGAGATTAAATAGAATTGAAGGACA
AGTTCGTGCTATCAACCGAATGATAGAAGAAGATGTTTATTGTGATGATGTTTTAACACAAATTAGAGCAACACGTTCAG
CTTTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAGAGTTGTATAACTGAAAAAGTCAATAATGGTCATCAA
GAAGAAGCCATGGAAGAGTTACTTGTAACTTTTCAAAAATTAATGAAAGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A654BGA3