Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 34171..34754 Replicon chromosome
Accession NZ_CP031280
Organism Staphylococcus pasteuri strain 3C

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag DWB95_RS00140 Protein ID WP_070451747.1
Coordinates 34171..34509 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DWB95_RS00145 Protein ID WP_176745276.1
Coordinates 34506..34754 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB95_RS00125 30111..30590 + 480 WP_002466394.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
DWB95_RS00130 30861..32165 - 1305 WP_154873880.1 poly-gamma-glutamate hydrolase family protein -
DWB95_RS00135 32526..34025 + 1500 WP_154873882.1 NAD(P)H-binding protein -
DWB95_RS00140 34171..34509 - 339 WP_070451747.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB95_RS00145 34506..34754 - 249 WP_176745276.1 AbrB family transcriptional regulator Antitoxin
DWB95_RS00150 35045..35995 - 951 WP_154873884.1 ABC transporter substrate-binding protein -
DWB95_RS00155 36072..36776 + 705 WP_070451741.1 alpha/beta hydrolase -
DWB95_RS12510 36962..37120 + 159 WP_017638051.1 hypothetical protein -
DWB95_RS00160 37121..37699 + 579 WP_051522845.1 Fic family protein -
DWB95_RS00165 37985..38793 + 809 Protein_31 Cof-type HAD-IIB family hydrolase -
DWB95_RS00170 39096..39593 + 498 WP_070451737.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13132.24 Da        Isoelectric Point: 8.8818

>T108825 WP_070451747.1 NZ_CP031280:c34509-34171 [Staphylococcus pasteuri]
MSIKQFDILYIDLDPTRGREKQKIRPCLVINNQMSIEGTDFVWVLPITNREVRFPTDIEVKTKKGLVTGVIDTIQIRSLD
LNVRYHNYRDELQDNLKKDVLQAVQTYLKPTL

Download         Length: 339 bp

>T108825 NZ_CP031280:c34509-34171 [Staphylococcus pasteuri]
ATGAGTATAAAACAATTCGACATACTTTATATTGACCTAGATCCAACACGTGGTCGTGAAAAACAAAAGATACGTCCATG
TCTAGTTATAAACAATCAAATGAGCATTGAAGGTACTGATTTTGTTTGGGTATTACCAATCACAAATCGAGAAGTAAGAT
TTCCCACTGACATTGAAGTCAAAACTAAAAAAGGATTAGTTACAGGTGTCATAGATACTATTCAAATACGCTCACTAGAT
CTCAATGTTCGTTATCATAACTATAGAGATGAATTACAAGACAACTTAAAAAAGGATGTACTACAAGCGGTACAGACGTA
TTTAAAACCTACTTTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9297.45 Da        Isoelectric Point: 5.1745

>AT108825 WP_176745276.1 NZ_CP031280:c34754-34506 [Staphylococcus pasteuri]
MNKTSERIFKNGNSKAMSLSKQTIQLANFDVGDKVEVQEMNGGLFIKKKEESIEDRITNFFKNGGKYTETEIDFGESVGR
EI

Download         Length: 249 bp

>AT108825 NZ_CP031280:c34754-34506 [Staphylococcus pasteuri]
ATGAATAAAACGTCTGAACGCATTTTCAAAAATGGTAATAGTAAAGCTATGAGCTTAAGTAAACAAACGATTCAACTCGC
TAATTTCGACGTAGGGGATAAAGTTGAGGTTCAAGAAATGAATGGTGGATTATTTATCAAAAAAAAAGAAGAATCGATTG
AAGATAGAATTACAAATTTTTTCAAGAATGGTGGTAAATACACTGAAACTGAAATTGATTTTGGCGAAAGTGTAGGTCGT
GAGATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References