Detailed information of TA system TA108824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 930195..930990
• Replicon: chromosome
• Accession: NZ_CP031277
• Organism: Staphylococcus hominis strain 19A

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: DWB94_RS04705
• Protein ID: WP_017176399.1
• Coordinates: 930823..930990 (+)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A4Q9WMK1
• Locus tag: DWB94_RS04700
• Protein ID: WP_017176400.1
• Coordinates: 930195..930794 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB94_RS04680	926010..927464	+	1455	WP_070436372.1	ABC transporter substrate-binding protein/permease	-
DWB94_RS04685	927457..928179	+	723	WP_019835687.1	amino acid ABC transporter ATP-binding protein	-
DWB94_RS04690	928441..929562	+	1122	WP_019835688.1	tRNA epoxyqueuosine(34) reductase QueG	-
DWB94_RS04695	929565..930035	+	471	WP_017176401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DWB94_RS04700	930195..930794	+	600	WP_017176400.1	glucosamine-6-phosphate isomerase	Antitoxin
DWB94_RS04705	930823..930990	+	168	WP_017176399.1	hypothetical protein	Toxin
DWB94_RS04710	931101..931493	+	393	WP_017176398.1	hypothetical protein	-
DWB94_RS04715	931633..933018	+	1386	WP_017176397.1	class II fumarate hydratase	-
DWB94_RS04720	933097..933921	-	825	WP_019835689.1	RluA family pseudouridine synthase	-
DWB94_RS04725	934059..935168	+	1110	WP_017176395.1	GAF domain-containing sensor histidine kinase	-
DWB94_RS04730	935183..935806	+	624	WP_017176394.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL	695057..1019483	324426

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6478.81 Da
• Isoelectric Point: 3.9837

>T108824 WP_017176399.1 NZ_CP031277:930823-930990 [Staphylococcus hominis]
MSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 168 bp

>T108824 NZ_CP031277:930823-930990 [Staphylococcus hominis]
ATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGGATGATTTAGAAGCATTAGG
AAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTTCAGATT
TAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22375.22 Da
• Isoelectric Point: 4.9712

>AT108824 WP_017176400.1 NZ_CP031277:930195-930794 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNSGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT108824 NZ_CP031277:930195-930794 [Staphylococcus hominis]
ATGGCAATGAATTTTAAAGTATTCGAAGATAAACAACATGCAGCAGACTATGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGTTTCCATTTAAACAAGGATTCTGCACCTGTATTAGATGAATTAAAAAAATCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGACTATGACGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAGCAAGTATATTCTATTAGTCTTGATGATGATGCTGAATCATTAATCAATGATAGAATTAAAACAAAAGAAAA
TAAAGGAAAACTTACTTTACAAGTTGTTTCAATTGATAACTCTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AGGCACGCGAAATTATCTTAGTTGTAACTGGTGCTGAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAACTTTTTACCTGCTGATTTAAAAGTACATCGTATGGTAACAGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
AGAAGACGTTAAAGAATACTTCACAGCGAGATTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A4Q9WMK1