108823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 785413..785942 Replicon chromosome
Accession NZ_CP031277
Organism Staphylococcus hominis strain 19A

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag DWB94_RS03850 Protein ID WP_017174798.1
Coordinates 785580..785942 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag DWB94_RS03845 Protein ID WP_002448681.1
Coordinates 785413..785583 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB94_RS03820 781318..781797 + 480 WP_017174793.1 PH domain-containing protein -
DWB94_RS03825 781787..783289 + 1503 WP_017174794.1 PH domain-containing protein -
DWB94_RS03830 783282..783758 + 477 WP_017174795.1 PH domain-containing protein -
DWB94_RS03835 783786..784139 + 354 WP_017174796.1 holo-ACP synthase -
DWB94_RS03840 784182..785327 + 1146 WP_017174797.1 alanine racemase -
DWB94_RS03845 785413..785583 + 171 WP_002448681.1 hypothetical protein Antitoxin
DWB94_RS03850 785580..785942 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB94_RS03855 786314..787315 + 1002 WP_017174799.1 PP2C family protein-serine/threonine phosphatase -
DWB94_RS03860 787401..787727 + 327 WP_002448686.1 anti-sigma factor antagonist -
DWB94_RS03865 787729..788208 + 480 WP_002448683.1 anti-sigma B factor RsbW -
DWB94_RS03870 788183..788953 + 771 WP_017174800.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 695057..1019483 324426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T108823 WP_017174798.1 NZ_CP031277:785580-785942 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T108823 NZ_CP031277:785580-785942 [Staphylococcus hominis]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTAATCGTTGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACACATGTAGAAATAGAAAAGAAAAAATATCGTTTAGATAAAGATTCAGTCATTCTTTTAGAACAAATACGA
ACATTAGATAAAAAAAGATTGAAAGAGAAACTTACATATTTATCAGAAGATAAAATGAAAGAAGTTGACGATGCATTGGA
TATCAGTTTAGGTTTACACGATGTTCGTCCTCAAAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT108823 WP_002448681.1 NZ_CP031277:785413-785583 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT108823 NZ_CP031277:785413-785583 [Staphylococcus hominis]
ATGTTAACTTTTAATCAGAATAGAAGCCATAGTCTTGAACAATCATTAAAAGAGGGCTATGTCCAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCATTTCCATTAGAATGTGAAGCTTGTGATTGTAACGAATCATATCTTACATCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References