108822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 774397..774915 Replicon chromosome
Accession NZ_CP031277
Organism Staphylococcus hominis strain 19A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1K1Z7E3
Locus tag DWB94_RS03790 Protein ID WP_048787783.1
Coordinates 774706..774915 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag DWB94_RS03785 Protein ID WP_002437530.1
Coordinates 774397..774690 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB94_RS03760 769623..770411 + 789 WP_017175143.1 hydroxyethylthiazole kinase -
DWB94_RS03765 770414..771052 + 639 WP_048787784.1 thiamine phosphate synthase -
DWB94_RS03770 771141..772010 + 870 WP_002455066.1 membrane protein insertase YidC -
DWB94_RS03775 772068..772715 - 648 WP_002448635.1 HD domain-containing protein -
DWB94_RS03780 772750..774234 - 1485 WP_017174787.1 cardiolipin synthase -
DWB94_RS03785 774397..774690 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
DWB94_RS03790 774706..774915 + 210 WP_048787783.1 heavy-metal-associated domain-containing protein Toxin
DWB94_RS03795 775028..775165 + 138 WP_002437525.1 hypothetical protein -
DWB94_RS03800 775326..776510 - 1185 WP_048787782.1 rod shape-determining protein RodA -
DWB94_RS03805 776886..777956 + 1071 WP_017174790.1 D-alanine--D-alanine ligase -
DWB94_RS03810 777972..779327 + 1356 WP_049420259.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 695057..1019483 324426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(8-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7941.98 Da        Isoelectric Point: 4.0857

>T108822 WP_048787783.1 NZ_CP031277:774706-774915 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T108822 NZ_CP031277:774706-774915 [Staphylococcus hominis]
ATGTTAAACAGTAATATTGTATTTATAGATAACATTGAAACAGAAGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACAGTATCAATCGATATAGAAAGAAATAAGGTTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT108822 WP_002437530.1 NZ_CP031277:774397-774690 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT108822 NZ_CP031277:774397-774690 [Staphylococcus hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATCGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTGGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACTGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1Z7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References