Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 949782..950311 Replicon chromosome
Accession NZ_CP031275
Organism Staphylococcus xylosus strain

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4NYG1
Locus tag DWB98_RS04395 Protein ID WP_047172098.1
Coordinates 949949..950311 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D4YKY9
Locus tag DWB98_RS04390 Protein ID WP_017722121.1
Coordinates 949782..949952 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB98_RS04365 945559..946038 + 480 WP_047172094.1 PH domain-containing protein -
DWB98_RS04370 946031..947539 + 1509 WP_107542699.1 PH domain-containing protein -
DWB98_RS04375 947526..948017 + 492 WP_042362336.1 PH domain-containing protein -
DWB98_RS04380 948079..948432 + 354 WP_042362337.1 holo-ACP synthase -
DWB98_RS04385 948546..949694 + 1149 WP_047172097.1 alanine racemase -
DWB98_RS04390 949782..949952 + 171 WP_017722121.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DWB98_RS04395 949949..950311 + 363 WP_047172098.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB98_RS04400 950660..951661 + 1002 WP_047172099.1 PP2C family protein-serine/threonine phosphatase -
DWB98_RS04405 951741..952067 + 327 WP_029377954.1 anti-sigma factor antagonist -
DWB98_RS04410 952069..952551 + 483 WP_029377953.1 anti-sigma B factor RsbW -
DWB98_RS04415 952526..953296 + 771 WP_047172100.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13551.81 Da        Isoelectric Point: 10.3173

>T108817 WP_047172098.1 NZ_CP031275:949949-950311 [Staphylococcus xylosus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEKKMKEVNIAIDISLGLHNIRNHKS

Download         Length: 363 bp

>T108817 NZ_CP031275:949949-950311 [Staphylococcus xylosus]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTATCACCAGTACAAGGGTCTGAACAAGGGGGAATTAGACCCGTCGT
TATTATACAAAACGATACTGGTAACAAATATAGTCCTACAGTAATTGTAGCTGCAATTACTGGTAGGATTAATAAAGCTA
AAATACCTACACATGTAGAGATAGAAAAAAGTAAATATAAACTTGATAAAGATTCTGTTATATTGTTAGAACAAATCAGA
ACTTTAGATAAAAATAGGCTAAAGGAAAAATTAACATATCTTTCTGAGAAAAAAATGAAAGAAGTTAATATTGCTATTGA
TATAAGTTTAGGATTACATAATATTAGGAATCATAAATCCTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT108817 WP_017722121.1 NZ_CP031275:949782-949952 [Staphylococcus xylosus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT108817 NZ_CP031275:949782-949952 [Staphylococcus xylosus]
ATGGCAAGTTTTAATCAAAGTAGAAATCATAGTATTGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGACTTAAA
TCTCTCCCTTGCAGCAGAAGCCTTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACATTAGCTCTAAGAATA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4NYG1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D4YKY9

References