Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 938157..938665 Replicon chromosome
Accession NZ_CP031275
Organism Staphylococcus xylosus strain

Toxin (Protein)


Gene name TsdT Uniprot ID A0A5R9B1P1
Locus tag DWB98_RS04335 Protein ID WP_042362331.1
Coordinates 938465..938665 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A418I4X8
Locus tag DWB98_RS04330 Protein ID WP_029377967.1
Coordinates 938157..938450 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB98_RS04305 933273..934061 + 789 WP_047172092.1 hydroxyethylthiazole kinase -
DWB98_RS04310 934064..934702 + 639 WP_047172093.1 thiamine phosphate synthase -
DWB98_RS04315 934790..935659 + 870 WP_029377970.1 membrane protein insertase YidC -
DWB98_RS04320 935771..936379 - 609 WP_171031846.1 HD domain-containing protein -
DWB98_RS04325 936530..938014 - 1485 WP_042362330.1 cardiolipin synthase -
DWB98_RS04330 938157..938450 + 294 WP_029377967.1 copper-sensing transcriptional repressor CsoR Antitoxin
DWB98_RS04335 938465..938665 + 201 WP_042362331.1 heavy-metal-associated domain-containing protein Toxin
DWB98_RS04340 938881..939021 + 141 WP_099265859.1 hypothetical protein -
DWB98_RS04345 939365..940570 - 1206 WP_042362332.1 rod shape-determining protein RodA -
DWB98_RS04350 940822..941892 + 1071 WP_038678888.1 D-alanine--D-alanine ligase -
DWB98_RS04355 941905..943260 + 1356 WP_042362333.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-64)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7517.53 Da        Isoelectric Point: 4.5845

>T108816 WP_042362331.1 NZ_CP031275:938465-938665 [Staphylococcus xylosus]
VQSKVIYVSGINSERQYQIKQRLMNVIGVHSVAIDSDKGEILVDFETPASLNNLEKEIYDLGYQIF

Download         Length: 201 bp

>T108816 NZ_CP031275:938465-938665 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGGTATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAGTGTTGCTATAGATAGTGATAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.85 Da        Isoelectric Point: 6.8624

>AT108816 WP_029377967.1 NZ_CP031275:938157-938450 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT108816 NZ_CP031275:938157-938450 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAGTTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9B1P1

Antitoxin

Source ID Structure
AlphaFold DB A0A418I4X8

References