Detailed information of TA system TA108815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 937761..938542
• Replicon: chromosome
• Accession: NZ_CP031274
• Organism: Staphylococcus chromogenes strain 17A

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: DWB97_RS11765
• Protein ID: WP_157946118.1
• Coordinates: 938378..938542 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: DWB97_RS04720
• Protein ID: WP_145400690.1
• Coordinates: 937761..938360 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB97_RS04700	933945..934667	+	723	WP_145400687.1	amino acid ABC transporter ATP-binding protein	-
DWB97_RS04705	934955..936088	+	1134	WP_037577244.1	tRNA epoxyqueuosine(34) reductase QueG	-
DWB97_RS04710	936085..936555	+	471	WP_145400688.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DWB97_RS04715	936573..937742	+	1170	WP_145400689.1	N-acetylglucosamine-6-phosphate deacetylase	-
DWB97_RS04720	937761..938360	+	600	WP_145400690.1	glucosamine-6-phosphate isomerase	Antitoxin
DWB97_RS11765	938378..938542	+	165	WP_157946118.1	hypothetical protein	Toxin
DWB97_RS04725	938642..939052	+	411	WP_145400691.1	hypothetical protein	-
DWB97_RS04730	939197..940582	+	1386	WP_037577233.1	class II fumarate hydratase	-
DWB97_RS04735	940604..942130	+	1527	WP_145400692.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6306.69 Da
• Isoelectric Point: 3.9165

>T108815 WP_157946118.1 NZ_CP031274:938378-938542 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISEANDEEKVNQTHDASIRSDKTEE

Nucleotide

• Length: 165 bp

>T108815 NZ_CP031274:938378-938542 [Staphylococcus chromogenes]
ATGACAGAAGAAAAACATATCGAACATGAAAACGAAATGGTCGATGATTTTGATGATCTTGTCAGTTTAGGGAAAGAAAT
GGAACAAATTTCTGAAGCGAATGACGAAGAAAAAGTGAACCAAACACATGACGCATCTATTCGTTCAGATAAAACTGAAG
AATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22368.30 Da
• Isoelectric Point: 5.8826

>AT108815 WP_145400690.1 NZ_CP031274:937761-938360 [Staphylococcus chromogenes]
MAMNFKIFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDDHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHEIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT108815 NZ_CP031274:937761-938360 [Staphylococcus chromogenes]
ATGGCAATGAACTTTAAAATTTTTAAAGACAAAGATACTGCAGCAATTTATGCAGCAGATATCATCAGAAAACAATTTAA
CAATAATCCAACGACAATTGCTGGATTTCATTTGAGTGGTGAAGAAGCACCGGTATTAGACTATTTAAAACGCAATGTAG
ATGATCATGCCGTAGATTTTAGTCAAATTCATGTGCTAGATTATGACAAGCAAACATCATATTTTAAAGCGTTAGGTGTA
CCTGAAAAACAAATTCATGAAATTCCAGAAGATGACGATGTTGAAAAATTTATCGAACATAAAGCGAAAACAAAAGATAA
TAAAGGTAAATTGACACTACAAGTTGTTTCTATTAATCAGAATGGTGAATTTGGAGTACCAGTGAACAATGGTTTAAAAC
CTGCGCGTGAAATTTTTGTCATTGTGACAGGACATGATAAAGCTGATGTTATTAAAAAGTTATATGAAGATAATGGTAAT
ACAAGCTTTATTCCATCAAGCTTAAAAACGCACCGTATGGTGAATGTCATTTTAGACGAAGCTGCAGCCCAAGGTTTGCC
AGCTGATGTCAGAGAATATTTCACTTCTCTATATGCATAA