Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 795565..796089 Replicon chromosome
Accession NZ_CP031274
Organism Staphylococcus chromogenes strain 17A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DWB97_RS03925 Protein ID WP_103159488.1
Coordinates 795736..796089 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3A0K2V6
Locus tag DWB97_RS03920 Protein ID WP_037577177.1
Coordinates 795565..795735 (+) Length 57 a.a.

Genomic Context

DWB97_RS03895DWB97_RS03900DWB97_RS03905DWB97_RS03910DWB97_RS03915DWB97_RS03920DWB97_RS03925DWB97_RS03930DWB97_RS03935DWB97_RS03940DWB97_RS03945
Location: 791413..791886 (474 bp)
Type: Others
Protein ID: WP_145400619.1
Location: 791879..793357 (1479 bp)
Type: Others
Protein ID: WP_145400620.1
Location: 793354..793869 (516 bp)
Type: Others
Protein ID: WP_165885554.1
Location: 793866..794216 (351 bp)
Type: Others
Protein ID: WP_145400622.1
Location: 794332..795480 (1149 bp)
Type: Others
Protein ID: WP_037577179.1
Location: 795565..795735 (171 bp)
Type: Antitoxin
Protein ID: WP_037577177.1
Location: 795736..796089 (354 bp)
Type: Toxin
Protein ID: WP_103159488.1
Location: 796153..797157 (1005 bp)
Type: Others
Protein ID: WP_145400623.1
Location: 797238..797564 (327 bp)
Type: Others
Protein ID: WP_145400624.1
Location: 797567..798046 (480 bp)
Type: Others
Protein ID: WP_037577169.1
Location: 798021..798791 (771 bp)
Type: Others
Protein ID: WP_037577167.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DWB97_RS03895791413..791886+474WP_145400619.1PH domain-containing protein-
DWB97_RS03900791879..793357+1479WP_145400620.1PH domain-containing protein-
DWB97_RS03905793354..793869+516WP_165885554.1PH domain-containing protein-
DWB97_RS03910793866..794216+351WP_145400622.1holo-ACP synthase-
DWB97_RS03915794332..795480+1149WP_037577179.1alanine racemase-
DWB97_RS03920795565..795735+171WP_037577177.1hypothetical proteinAntitoxin
DWB97_RS03925795736..796089+354WP_103159488.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DWB97_RS03930796153..797157+1005WP_145400623.1PP2C family protein-serine/threonine phosphatase-
DWB97_RS03935797238..797564+327WP_145400624.1anti-sigma factor antagonist-
DWB97_RS03940797567..798046+480WP_037577169.1anti-sigma B factor RsbW-
DWB97_RS03945798021..798791+771WP_037577167.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13064.34 Da        Isoelectric Point: 10.5127

>T108814 WP_103159488.1 NZ_CP031274:795736-796089 [Staphylococcus chromogenes]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T108814 NZ_CP031274:795736-796089 [Staphylococcus chromogenes]
ATGAAGCGTGGCGATGTTTATTTAGCGGATTTATCACCAGTACAAGGGTCAGAGCAAGGGGGAGTCAGACCTGTCGTTAT
TATTCAAAATGATACTGGTAATAAATACAGTCCGACCGTGATTGTTGCAGCGATTACAGGTCGCATCAATAAAGCGAAAA
TTCCAACGCATGTCGAAATTGATAAGAAAAAATATAAACTCGACAAAGATTCTGTTATTTTGTTAGAACAAATTAGAACA
GTCGATAAAAAGAGGCTTAAAGAAAAGCTCACCTTTCTTTCTGATAAAAAGATGAAAGAAGTCAATGCGGCACTTGGAAT
TAGCTTAGGATTGCACATGAATCAACACAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6328.01 Da        Isoelectric Point: 4.2313

>AT108814 WP_037577177.1 NZ_CP031274:795565-795735 [Staphylococcus chromogenes]
MSAFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYFVECEACDCNESHLLSNHKDD

Download         Length: 171 bp

>AT108814 NZ_CP031274:795565-795735 [Staphylococcus chromogenes]
ATGTCAGCATTCAATCAAACAAGAGTGAAAAGTTTAGAGCAATCTTTGAAAGAGGGGTATGTTCAGATGGCAGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTTTGTCGAATGTGAAGCATGTGATTGCAACGAATCACACTTACTTTCTAACCACA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3A0K2V6

References