Detailed information of TA system TA108812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2119435..2119911
• Replicon: chromosome
• Accession: NZ_CP031271
• Organism: Staphylococcus caprae strain 26D

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: C5QQH5
• Locus tag: DWB96_RS10175
• Protein ID: WP_002441631.1
• Coordinates: 2119723..2119911 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: C5QQH6
• Locus tag: DWB96_RS10170
• Protein ID: WP_002441634.1
• Coordinates: 2119435..2119692 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB96_RS10135	2114658..2115380	-	723	WP_002441649.1	type I 3-dehydroquinate dehydratase	-
DWB96_RS10140	2115550..2115972	+	423	WP_002441647.1	organic hydroperoxide resistance protein	-
DWB96_RS10145	2116367..2116873	+	507	WP_002441644.1	GNAT family N-acetyltransferase	-
DWB96_RS10150	2117071..2117691	+	621	WP_002441642.1	LysE family transporter	-
DWB96_RS10155	2117753..2118337	-	585	WP_037541214.1	phosphoglycerate mutase family protein	-
DWB96_RS10160	2118561..2118797	+	237	WP_002441638.1	hypothetical protein	-
DWB96_RS10165	2118789..2118992	-	204	WP_002441635.1	sterile alpha motif-like domain-containing protein	-
DWB96_RS10170	2119435..2119692	+	258	WP_002441634.1	hypothetical protein	Antitoxin
DWB96_RS10175	2119723..2119911	+	189	WP_002441631.1	hypothetical protein	Toxin
DWB96_RS10180	2120137..2120721	+	585	WP_145375891.1	hypothetical protein	-
DWB96_RS10185	2120785..2121018	-	234	WP_002441627.1	hypothetical protein	-
DWB96_RS10190	2121160..2121765	-	606	WP_002441625.1	GNAT family N-acetyltransferase	-
DWB96_RS10195	2121946..2122692	+	747	WP_044466334.1	poly-gamma-glutamate hydrolase family protein	-
DWB96_RS10200	2122809..2123096	+	288	WP_145376061.1	hypothetical protein	-
DWB96_RS10205	2123125..2123343	+	219	WP_002441617.1	hypothetical protein	-
DWB96_RS10210	2123645..2123971	+	327	WP_002441615.1	hypothetical protein	-
DWB96_RS10215	2124177..2124911	-	735	WP_037541208.1	SGNH/GDSL hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2115550..2134804	19254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-239)

Antitoxin

• Antitoxin SpoIISB (1-56)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7214.94 Da
• Isoelectric Point: 9.7844

>T108812 WP_002441631.1 NZ_CP031271:2119723-2119911 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Nucleotide

• Length: 189 bp

>T108812 NZ_CP031271:2119723-2119911 [Staphylococcus caprae]
ATGAATTTACATTTTCAAATATTATTATGGCTTTCAATTATATTCATTGTTGCTGGTGCAATTATTTTAGCCATTATGCT
TAAAACGAAAAAAGAAGAGAGAAAAGAATCTTATTTAGGTTTTACGGTTATTTTCTTAATTTTCGGCTTTGCAATGCTCA
TTTATACATTTATTTTTGGTATATTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9735.80 Da
• Isoelectric Point: 4.0612

>AT108812 WP_002441634.1 NZ_CP031271:2119435-2119692 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT108812 NZ_CP031271:2119435-2119692 [Staphylococcus caprae]
ATGAAAATAATTAGTGTAAATGTGATTAATATCATCTTAACCGTACTATTTATAGCTTTTAATGTACTCATTACCTATAA
TGCAAACGTTGATAATCACCTATGGTTAATACCAGGATTATGTATTTGTGGTATTGCTCTATTTACGAGTTTAACAATAG
CAATTATTTATACTGATCTTTTAAGTGAAATTTTGTTCTTTATTAATATTGTCTTAGCACTTTACTATATTTATCCAATT
TTTTATGACTTCCTATAG

Structures

Toxin

• AlphaFold DB: A0A1S1GRH8

Antitoxin

• AlphaFold DB: A0A1S1GRF3