Detailed information of TA system TA108811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1086586..1087389
• Replicon: chromosome
• Accession: NZ_CP031271
• Organism: Staphylococcus caprae strain 26D

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: C5QTI8
• Locus tag: DWB96_RS05270
• Protein ID: WP_002443566.1
• Coordinates: 1087210..1087389 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: DWB96_RS05265
• Protein ID: WP_037541523.1
• Coordinates: 1086586..1087185 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB96_RS05245	1082474..1083931	+	1458	WP_145375729.1	ABC transporter substrate-binding protein/permease	-
DWB96_RS05250	1083924..1084646	+	723	WP_002443573.1	amino acid ABC transporter ATP-binding protein	-
DWB96_RS05255	1084806..1085933	+	1128	WP_002443571.1	tRNA epoxyqueuosine(34) reductase QueG	-
DWB96_RS05260	1085936..1086406	+	471	WP_002443570.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DWB96_RS05265	1086586..1087185	+	600	WP_037541523.1	glucosamine-6-phosphate isomerase	Antitoxin
DWB96_RS05270	1087210..1087389	+	180	WP_002443566.1	hypothetical protein	Toxin
DWB96_RS05275	1087625..1088023	+	399	WP_002443564.1	hypothetical protein	-
DWB96_RS05280	1088176..1089561	+	1386	WP_002443562.1	class II fumarate hydratase	-
DWB96_RS05285	1089661..1090488	-	828	WP_002443561.1	RluA family pseudouridine synthase	-
DWB96_RS05290	1090667..1091779	+	1113	WP_002443558.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6967.41 Da
• Isoelectric Point: 3.9152

>T108811 WP_002443566.1 NZ_CP031271:1087210-1087389 [Staphylococcus caprae]
MAKEQESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLQDK

Nucleotide

• Length: 180 bp

>T108811 NZ_CP031271:1087210-1087389 [Staphylococcus caprae]
ATGGCTAAAGAACAAGAATCTAAATTGAATTATCATGAAGAAGAAAATGCAATGGTGACAGATTTAGATGATTTGAAAGA
ATTAGGTAAAGAAATGGAGCAAATTTCAGAAGAGAATGATGAAGACAAACTGAATCAATCTCATGACGAAGACGTACGTT
CCGACCTACAAGATAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22694.63 Da
• Isoelectric Point: 4.7838

>AT108811 WP_037541523.1 NZ_CP031271:1086586-1087185 [Staphylococcus caprae]
MAMNFKVFDNNERVAEYAADIIRKQFNNNPTTIAGFHLDKDQAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEKDAIEFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKRDVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFV

Nucleotide

• Length: 600 bp

>AT108811 NZ_CP031271:1086586-1087185 [Staphylococcus caprae]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGAAAGAGTAGCAGAATACGCTGCTGATATTATTCGTAAACAATTTAA
TAACAATCCTACAACAATTGCAGGATTTCATTTAGACAAGGACCAAGCGCCTGTTTTAGATGAACTTAAGAAAAACGTTG
ATACACACGCTGTAGACTTTAGTCAAATCAATATCTTAGATTATGACGACAATCGCTCTTATTATGAAGCTTTAGGAGTA
CCTGAAAGTCAAGTTTATTCAATCTCTTATGAAAAAGATGCAATTGAATTTATCTCAGATAAAATGAAAACGAAAGAAAA
TAAAGGAAAATTAATCCTTCAAGTTCTTTCTATAGATGAAAGTGGCAAATTAGATGTTAGCGTACGACAAGGTTTAATGG
AAGCTAGAGAAATCTTCTTAGTAGTCACTGGTAGCAATAAACGTGATGTGATTGAGAAATTATATCGTGAAAATGGTAAA
TCTAGTTATGAACCAGCAGATTTAAAAGCACATCGTATGGTTAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTTAAAGAGTACTTCACAGCACGTTTTGTCTAA

Structures

Toxin

• AlphaFold DB: A0A1J3ZT52