Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 913773..914302 Replicon chromosome
Accession NZ_CP031271
Organism Staphylococcus caprae strain 26D

Toxin (Protein)


Gene name mazF Uniprot ID C5QLA1
Locus tag DWB96_RS04285 Protein ID WP_002445525.1
Coordinates 913940..914302 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S1GX41
Locus tag DWB96_RS04280 Protein ID WP_037541853.1
Coordinates 913773..913943 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB96_RS04255 909588..910067 + 480 WP_044466354.1 PH domain-containing protein -
DWB96_RS04260 910060..911559 + 1500 WP_044466353.1 PH domain-containing protein -
DWB96_RS04265 911546..912088 + 543 WP_044466352.1 PH domain-containing protein -
DWB96_RS04270 912103..912459 + 357 WP_044466351.1 holo-ACP synthase -
DWB96_RS04275 912537..913685 + 1149 WP_002445529.1 alanine racemase -
DWB96_RS04280 913773..913943 + 171 WP_037541853.1 hypothetical protein Antitoxin
DWB96_RS04285 913940..914302 + 363 WP_002445525.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB96_RS04290 914674..915675 + 1002 WP_044466350.1 PP2C family protein-serine/threonine phosphatase -
DWB96_RS04295 915778..916104 + 327 WP_037541852.1 anti-sigma factor antagonist -
DWB96_RS04300 916106..916585 + 480 WP_002445522.1 anti-sigma B factor RsbW -
DWB96_RS04305 916560..917330 + 771 WP_002445521.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.68 Da        Isoelectric Point: 10.0250

>T108810 WP_002445525.1 NZ_CP031271:913940-914302 [Staphylococcus caprae]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHPKS

Download         Length: 363 bp

>T108810 NZ_CP031271:913940-914302 [Staphylococcus caprae]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTCGT
TATTATTCAAAACGATACTGGTAATAAATATAGTCCTACAGTCATTGTGGCTGCTATTACAGGTAGGATTAATAAAGCGA
AAATACCAACCCATGTAGAAATTGAAAAGAAAAAGTACAAGTTAGATAAAGATTCCGTTATCCTACTTGAACAAATTAGA
ACACTTGATAAAAAACGATTAAAAGAAAAATTGACCTATTTATCTGAAAGTAAGATGAAAGAGGTCGACAACGCCCTAGA
CATTAGTCTAGGCTTACATAACTTTGATCATCCAAAATCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6290.90 Da        Isoelectric Point: 4.0121

>AT108810 WP_037541853.1 NZ_CP031271:913773-913943 [Staphylococcus caprae]
MLSFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT108810 NZ_CP031271:913773-913943 [Staphylococcus caprae]
ATGTTATCTTTTAATCAAAATAGAAGTCACAGTCTTGAACAATCCTTAAAAGAAGGTTATGCACAAATGGCTGATCTAAA
CCTCTCCCTAGCGACGGAAGCTTTCCCGATTGAGTGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GUI8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GX41

References