Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1619555..1620358 Replicon chromosome
Accession NZ_CP031266
Organism Staphylococcus agnetis strain 12B

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DWB91_RS07900 Protein ID WP_145052115.1
Coordinates 1619897..1620358 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DWB91_RS07895 Protein ID WP_145052112.1
Coordinates 1619555..1619884 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB91_RS07845 1614866..1615084 - 219 WP_145052083.1 DUF2483 family protein -
DWB91_RS07850 1615081..1615350 - 270 WP_145052086.1 hypothetical protein -
DWB91_RS07855 1615741..1616067 - 327 WP_145052089.1 DUF771 domain-containing protein -
DWB91_RS11595 1616218..1616835 + 618 WP_186434585.1 hypothetical protein -
DWB91_RS07865 1616983..1617210 - 228 WP_145052095.1 hypothetical protein -
DWB91_RS07870 1617210..1617710 - 501 WP_145052098.1 ORF6C domain-containing protein -
DWB91_RS07875 1617772..1617984 + 213 WP_145052101.1 hypothetical protein -
DWB91_RS07880 1618011..1618205 - 195 WP_145052103.1 hypothetical protein -
DWB91_RS07885 1618217..1619101 - 885 WP_145052106.1 DUF3102 domain-containing protein -
DWB91_RS07890 1619115..1619363 - 249 WP_145052109.1 helix-turn-helix domain-containing protein -
DWB91_RS07895 1619555..1619884 + 330 WP_145052112.1 helix-turn-helix domain-containing protein Antitoxin
DWB91_RS07900 1619897..1620358 + 462 WP_145052115.1 ImmA/IrrE family metallo-endopeptidase Toxin
DWB91_RS11600 1620743..1620919 + 177 WP_186434587.1 hypothetical protein -
DWB91_RS07905 1621225..1621413 + 189 WP_145052118.1 hypothetical protein -
DWB91_RS07910 1621441..1621806 + 366 WP_145052120.1 hypothetical protein -
DWB91_RS07915 1621930..1622886 + 957 WP_186434589.1 Abi family protein -
DWB91_RS07920 1622941..1623966 + 1026 WP_145052126.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1611926..1633461 21535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-115)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18148.69 Da        Isoelectric Point: 6.3801

>T108807 WP_145052115.1 NZ_CP031266:1619897-1620358 [Staphylococcus agnetis]
MGLYEETLIQHDYIEVREANVLPDNLDGVWLGDLILIKRNLPERKKVEVLFEELAHHKLTYGNILDQSQFNNRKFENYAR
RYSYETSMPLSGIVEAFKQGVHNLYELANFFEISECHVLDCIEHYKKKYGIGTHYGKYSITFDPLRVFEVRRI

Download         Length: 462 bp

>T108807 NZ_CP031266:1619897-1620358 [Staphylococcus agnetis]
ATGGGATTATACGAAGAAACTTTAATACAACATGACTATATAGAAGTAAGAGAGGCGAATGTGCTTCCTGATAATTTAGA
TGGGGTATGGCTAGGAGATTTAATATTAATTAAACGTAACTTGCCAGAAAGGAAGAAAGTCGAAGTCCTCTTTGAAGAGT
TAGCCCACCACAAACTTACATACGGCAACATTTTAGATCAATCACAGTTCAACAACCGAAAATTCGAGAATTACGCAAGA
CGCTACTCATACGAAACATCTATGCCTCTATCAGGTATAGTCGAAGCGTTTAAGCAAGGTGTACACAATCTGTATGAGCT
TGCTAATTTTTTTGAGATTTCAGAATGTCACGTACTAGATTGTATTGAGCATTATAAAAAGAAGTATGGTATCGGAACTC
ACTACGGCAAATATTCTATTACATTTGACCCGTTGAGGGTTTTTGAGGTGAGGAGGATTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12757.36 Da        Isoelectric Point: 7.2039

>AT108807 WP_145052112.1 NZ_CP031266:1619555-1619884 [Staphylococcus agnetis]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDDEWQRVLDYADYIRSRRK

Download         Length: 330 bp

>AT108807 NZ_CP031266:1619555-1619884 [Staphylococcus agnetis]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATCGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAACAACCACAGCAC
CGTGCAGCTCATTTAGAGGGAGAGCTAACTGATGATGAGTGGCAACGCGTGTTAGATTATGCAGATTATATTAGAAGTAG
ACGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References