Detailed information of TA system TA108806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 951504..952277
• Replicon: chromosome
• Accession: NZ_CP031266
• Organism: Staphylococcus agnetis strain 12B

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: DWB91_RS11565
• Protein ID: WP_165804964.1
• Coordinates: 952122..952277 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: DWB91_RS04655
• Protein ID: WP_145051501.1
• Coordinates: 951504..952103 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB91_RS04635	947808..948530	+	723	WP_107368902.1	amino acid ABC transporter ATP-binding protein	-
DWB91_RS04640	948702..949829	+	1128	WP_145051498.1	tRNA epoxyqueuosine(34) reductase QueG	-
DWB91_RS04645	949832..950302	+	471	WP_060551401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
DWB91_RS04650	950317..951486	+	1170	WP_103346439.1	N-acetylglucosamine-6-phosphate deacetylase	-
DWB91_RS04655	951504..952103	+	600	WP_145051501.1	glucosamine-6-phosphate isomerase	Antitoxin
DWB91_RS11565	952122..952277	+	156	WP_165804964.1	hypothetical protein	Toxin
DWB91_RS04660	952436..952837	+	402	WP_060551398.1	hypothetical protein	-
DWB91_RS04665	952994..954379	+	1386	WP_060551397.1	class II fumarate hydratase	-
DWB91_RS04670	954401..955927	+	1527	WP_145051504.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6027.40 Da
• Isoelectric Point: 3.9813

>T108806 WP_165804964.1 NZ_CP031266:952122-952277 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPNIRSDQ

Nucleotide

• Length: 156 bp

>T108806 NZ_CP031266:952122-952277 [Staphylococcus agnetis]
ATGTCTGATGAAAAGCATATTGAACATGAAAATGAAATGGTAGATAATTTCGAAGATCTCGTTCAATTAGGTAAAGAAAT
GGAACAGATTTCTGAGACAAATGATCAAGATAAAGTCAATCAATCACATGACCCGAATATTCGTTCAGATCAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22467.38 Da
• Isoelectric Point: 5.3398

>AT108806 WP_145051501.1 NZ_CP031266:951504-952103 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVFDYLKHNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEQKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKTDVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT108806 NZ_CP031266:951504-952103 [Staphylococcus agnetis]
ATGGCAATGAACTTTAAAGTATTTAAAGACAAAGATACTGTAGCGGTTTATGCGGCAGATATCATTCGAAAACAATTTAA
TAATAATCCAACGACGATAGCAGGATTTCATCTTAGTGAAGAGGAAGCGCCTGTCTTTGACTATTTAAAACATAATGTTA
ACGACCATGCAGTTGATTTTAGTCAAATTCACATTTTAGATTATGATAAACAAGCGTCATATTTTAAGGCTCTTGGTGTA
CCTGAAAAACAAATTCATGAAATCCCAGAAGAAGACGAAGTAGAAAAATTCATTGAACAAAAAGCGAAAACGAAAGACAA
TAAAGGTAAACTTACATTACAAGTAGTGTCTATTAATAATAAAGGGGAATTTGGTGTCCCTGTTAATAATGGCTTAAAAC
CAGCACGCGAGATTTTTGTTGTTGTGACTGGAAGCGATAAAACGGATGTGATTAAAAAATTATATGAGGATAATGGTAAT
ACGAGCTTTATTCCTTCTAGTTTGAAAACACACCGTATGGTGAATGTGATTCTTGATGAAGCTGCAGCTCAAGGATTACC
GGATGACGTAAGAGAATATTTCACTTCTCTTTATGCATAA