Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 814147..814671 Replicon chromosome
Accession NZ_CP031266
Organism Staphylococcus agnetis strain 12B

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag DWB91_RS03880 Protein ID WP_037567539.1
Coordinates 814318..814671 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A242VEK4
Locus tag DWB91_RS03875 Protein ID WP_060551514.1
Coordinates 814147..814317 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB91_RS03850 809940..810416 + 477 WP_060551519.1 PH domain-containing protein -
DWB91_RS03855 810409..811896 + 1488 WP_145051422.1 PH domain-containing protein -
DWB91_RS03860 811880..812386 + 507 WP_157950536.1 PH domain-containing protein -
DWB91_RS03865 812458..812808 + 351 WP_145051427.1 holo-ACP synthase -
DWB91_RS03870 812914..814062 + 1149 WP_145051430.1 alanine racemase -
DWB91_RS03875 814147..814317 + 171 WP_060551514.1 hypothetical protein Antitoxin
DWB91_RS03880 814318..814671 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DWB91_RS03885 814731..815735 + 1005 WP_060551513.1 PP2C family protein-serine/threonine phosphatase -
DWB91_RS03890 815816..816142 + 327 WP_037567545.1 anti-sigma factor antagonist -
DWB91_RS03895 816145..816624 + 480 WP_037567547.1 anti-sigma B factor RsbW -
DWB91_RS03900 816599..817369 + 771 WP_060551512.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T108805 WP_037567539.1 NZ_CP031266:814318-814671 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T108805 NZ_CP031266:814318-814671 [Staphylococcus agnetis]
ATGAAACGTGGCGACGTTTATTTAGCAGATTTATCGCCAGTTCAAGGGTCGGAACAAGGGGGAGTCAGACCTGTCGTTAT
CATTCAAAATGATACTGGCAATAAGTATAGTCCAACGGTTATAGTAGCTGCAATTACTGGACGCATTAATAAAGCAAAAA
TTCCAACACATGTTGAAATTGAAAAACATAAATATAAGCTCGATAAAGATTCAGTTATCTTATTAGAACAAATAAGAACT
GTCGATAAAAAGAGACTTAAAGAAAAGTTGACATATCTTTCAGATAAAAAGATGAAAGAAGTGAACGCTGCACTTGGAAT
TAGTCTAGGATTGCACATGAACCAACATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT108805 WP_060551514.1 NZ_CP031266:814147-814317 [Staphylococcus agnetis]
MSAFYQIRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT108805 NZ_CP031266:814147-814317 [Staphylococcus agnetis]
ATGTCAGCATTCTATCAAATAAGAGGTAAAAGCTTAGAACAATCATTAAAAGAAGGGTATGTTCAGATGGCGGATTTAAA
TCTCTCCCTAGCAACTGAAGCATACTCAGTCGAGTGTGAAGCTTGTGACTGTAACGAAACACACTTATTATCTAACAATA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A242VEK4

References