Detailed information of TA system TA108797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2067041..2067570
• Replicon: chromosome
• Accession: NZ_CP031265
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DWB87_RS10480
• Protein ID: WP_000621175.1
• Coordinates: 2067041..2067403 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: DWB87_RS10485
• Protein ID: WP_000948331.1
• Coordinates: 2067400..2067570 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB87_RS10460	2064019..2064789	-	771	WP_001041108.1	RNA polymerase sigma factor SigB	-
DWB87_RS10465	2064764..2065243	-	480	WP_001190830.1	anti-sigma B factor RsbW	-
DWB87_RS10470	2065245..2065571	-	327	WP_001052491.1	anti-sigma factor antagonist	-
DWB87_RS10475	2065690..2066691	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
DWB87_RS10480	2067041..2067403	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DWB87_RS10485	2067400..2067570	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
DWB87_RS10490	2067655..2068803	-	1149	WP_001281154.1	alanine racemase	-
DWB87_RS10495	2068869..2069228	-	360	WP_000581197.1	holo-ACP synthase	-
DWB87_RS10500	2069232..2069723	-	492	WP_001205912.1	PH domain-containing protein	-
DWB87_RS10505	2069710..2071293	-	1584	WP_001294626.1	PH domain-containing protein	-
DWB87_RS10510	2071286..2071765	-	480	WP_001287078.1	hypothetical protein	-
DWB87_RS10515	2071974..2072534	-	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T108797 WP_000621175.1 NZ_CP031265:c2067403-2067041 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T108797 NZ_CP031265:c2067403-2067041 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT108797 WP_000948331.1 NZ_CP031265:c2067570-2067400 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT108797 NZ_CP031265:c2067570-2067400 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1