Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 819607..820084 Replicon chromosome
Accession NZ_CP031265
Organism Staphylococcus aureus strain 13

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DWB87_RS04015 Protein ID WP_000052076.1
Coordinates 819607..819795 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DWB87_RS04020 Protein ID WP_001059690.1
Coordinates 819824..820084 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB87_RS03985 815597..816118 + 522 WP_000824464.1 hypothetical protein -
DWB87_RS03990 816459..817145 + 687 WP_001793574.1 thermonuclease family protein -
DWB87_RS03995 817502..817702 + 201 WP_001059082.1 cold-shock protein -
DWB87_RS04000 818198..818416 - 219 WP_000005886.1 hypothetical protein -
DWB87_RS04005 818478..818762 - 285 WP_001004401.1 hypothetical protein -
DWB87_RS04010 818850..819419 - 570 WP_001106654.1 hypothetical protein -
DWB87_RS04015 819607..819795 - 189 WP_000052076.1 hypothetical protein Toxin
DWB87_RS04020 819824..820084 - 261 WP_001059690.1 hypothetical protein Antitoxin
DWB87_RS04025 820424..820627 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DWB87_RS04030 820624..820860 - 237 WP_000368687.1 hypothetical protein -
DWB87_RS04035 821084..821665 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
DWB87_RS04040 821738..822355 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
DWB87_RS04045 822510..823004 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DWB87_RS04050 823403..823825 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
DWB87_RS04055 823973..824689 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T108790 WP_000052076.1 NZ_CP031265:c819795-819607 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T108790 NZ_CP031265:c819795-819607 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT108790 WP_001059690.1 NZ_CP031265:c820084-819824 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT108790 NZ_CP031265:c820084-819824 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References