Detailed information of TA system TA108789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2508077..2508711
• Replicon: chromosome
• Accession: NZ_CP031264
• Organism: Streptacidiphilus bronchialis strain DSM 106435

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C7M71_RS10910
• Protein ID: WP_111494727.1
• Coordinates: 2508077..2508496 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C7M71_RS10915
• Protein ID: WP_111494729.1
• Coordinates: 2508493..2508711 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M71_RS10890	2503644..2504810	-	1167	WP_111489608.1	adenylate/guanylate cyclase domain-containing protein	-
C7M71_RS10895	2505030..2505899	-	870	WP_111489616.1	biotin--[acetyl-CoA-carboxylase] ligase	-
C7M71_RS10900	2506172..2507767	+	1596	WP_111489609.1	acyl-CoA carboxylase subunit beta	-
C7M71_RS10905	2507836..2508057	+	222	WP_114914315.1	acyl-CoA carboxylase subunit epsilon	-
C7M71_RS10910	2508077..2508496	-	420	WP_111494727.1	PIN domain-containing protein	Toxin
C7M71_RS10915	2508493..2508711	-	219	WP_111494729.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
C7M71_RS10920	2508972..2509589	+	618	WP_111494731.1	septum formation inhibitor Maf	-
C7M71_RS10925	2509919..2511691	+	1773	WP_111494733.1	biotin/lipoyl-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (4-45)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15544.52 Da
• Isoelectric Point: 6.9797

>T108789 WP_111494727.1 NZ_CP031264:c2508496-2508077 [Streptacidiphilus bronchialis]
VIRYLIDSSALWRIQRDKDIRAAWAEVISEGVVGSCHPQRTEFRASARTSAEYEDMTRMFEALYDDVPVPKSAWRWIEAA
QYRLTRSGGHRALSVVDLLISATAAHAGLTVLHDHNDLVTAARSLDDLAERSVRRVPGG

Nucleotide

• Length: 420 bp

>T108789 NZ_CP031264:c2508496-2508077 [Streptacidiphilus bronchialis]
GTGATCCGCTACCTCATCGACTCCTCGGCCCTGTGGCGGATCCAGCGGGACAAGGACATCCGTGCGGCCTGGGCGGAGGT
GATCAGCGAGGGGGTCGTCGGCTCCTGCCATCCGCAGCGCACGGAGTTCAGGGCCTCCGCCCGCACCAGCGCGGAGTACG
AGGACATGACCCGCATGTTCGAAGCGCTCTATGACGACGTGCCGGTGCCCAAGAGCGCCTGGCGTTGGATCGAGGCGGCG
CAGTACCGGTTGACCCGCTCCGGCGGACACCGCGCGCTCTCCGTGGTGGACCTGCTGATCAGCGCCACCGCGGCGCACGC
GGGGCTCACCGTGCTGCATGACCACAATGACCTCGTGACGGCGGCGCGCTCGCTGGATGATCTGGCCGAGCGGTCCGTGC
GGCGGGTGCCCGGGGGGTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8138.13 Da
• Isoelectric Point: 5.0622

>AT108789 WP_111494729.1 NZ_CP031264:c2508711-2508493 [Streptacidiphilus bronchialis]
MSMTTLDLDDDALAAAMRLSGARTKKETVNLALREYAARHQRIDALERYAELAQDWDYEAWERAHGAAKGPM

Nucleotide

• Length: 219 bp

>AT108789 NZ_CP031264:c2508711-2508493 [Streptacidiphilus bronchialis]
ATGAGTATGACGACGCTCGACCTGGACGACGACGCGCTGGCGGCGGCCATGCGGCTGTCGGGCGCCAGGACCAAGAAGGA
GACCGTCAACCTGGCGCTTCGCGAGTACGCCGCTCGGCACCAGCGGATAGACGCCCTGGAGCGCTATGCCGAACTCGCGC
AGGACTGGGACTACGAGGCGTGGGAGCGGGCCCACGGCGCGGCGAAGGGCCCCATGTGA