Detailed information of TA system TA108783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/ElaA-DUF1778
• Location: 75382..76133
• Replicon: plasmid pL22-1
• Accession: NZ_CP031258
• Organism: Klebsiella quasipneumoniae strain L22

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: DV026_RS26070
• Protein ID: WP_048333033.1
• Coordinates: 75651..76133 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A071LPN3
• Locus tag: DV026_RS26065
• Protein ID: WP_004902250.1
• Coordinates: 75382..75660 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV026_RS26025	71588..72070	+	483	WP_172694439.1	hypothetical protein	-
DV026_RS26030	72314..72628	-	315	WP_023288299.1	hypothetical protein	-
DV026_RS26040	73051..74019	-	969	WP_004225014.1	IS5 family transposase	-
DV026_RS26055	74599..74940	+	342	WP_032437747.1	hypothetical protein	-
DV026_RS26060	75048..75260	+	213	WP_016946198.1	hypothetical protein	-
DV026_RS26065	75382..75660	+	279	WP_004902250.1	DUF1778 domain-containing protein	Antitoxin
DV026_RS26070	75651..76133	+	483	WP_048333033.1	GNAT family N-acetyltransferase	Toxin
DV026_RS26085	77168..77707	+	540	WP_004902239.1	hypothetical protein	-
DV026_RS26090	77812..78204	+	393	WP_032442757.1	hypothetical protein	-
DV026_RS26095	78305..79060	+	756	WP_004902235.1	DUF2971 domain-containing protein	-
DV026_RS26100	79087..79734	+	648	WP_014386537.1	EcsC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	iroB / iroC / iroD / iroN / rmpA / rmpA / iutA / iucD / iucC / iucB / iucA	1..212635	212635
	-	flank	IS/Tn	-	-	73051..73974	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-86)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17708.53 Da
• Isoelectric Point: 8.9130

>T108783 WP_048333033.1 NZ_CP031258:75651-76133 [Klebsiella quasipneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Nucleotide

• Length: 483 bp

>T108783 NZ_CP031258:75651-76133 [Klebsiella quasipneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGATGTCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGAAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10704.23 Da
• Isoelectric Point: 4.5271

>AT108783 WP_004902250.1 NZ_CP031258:75382-75660 [Klebsiella quasipneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Nucleotide

• Length: 279 bp

>AT108783 NZ_CP031258:75382-75660 [Klebsiella quasipneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACACCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A071LPN3