Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3870007..3870626 Replicon chromosome
Accession NZ_CP031257
Organism Klebsiella quasipneumoniae strain L22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DV026_RS19365 Protein ID WP_002892050.1
Coordinates 3870408..3870626 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DV026_RS19360 Protein ID WP_002892066.1
Coordinates 3870007..3870381 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV026_RS19350 3865160..3866353 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DV026_RS19355 3866376..3869522 + 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
DV026_RS19360 3870007..3870381 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DV026_RS19365 3870408..3870626 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DV026_RS19370 3870785..3871351 + 567 WP_004204750.1 maltose O-acetyltransferase -
DV026_RS29155 3871323..3871445 - 123 WP_032426076.1 hypothetical protein -
DV026_RS19375 3871488..3871958 + 471 WP_004204751.1 YlaC family protein -
DV026_RS19380 3871927..3873384 - 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
DV026_RS19385 3873485..3874183 + 699 WP_117985137.1 GNAT family N-acetyltransferase -
DV026_RS19390 3874180..3874320 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DV026_RS19395 3874320..3874583 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T108780 WP_002892050.1 NZ_CP031257:3870408-3870626 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T108780 NZ_CP031257:3870408-3870626 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT108780 WP_002892066.1 NZ_CP031257:3870007-3870381 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT108780 NZ_CP031257:3870007-3870381 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References