Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816360..817017 Replicon chromosome
Accession NZ_CP031257
Organism Klebsiella quasipneumoniae strain L22

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag DV026_RS04200 Protein ID WP_004205323.1
Coordinates 816607..817017 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DV026_RS04195 Protein ID WP_002916312.1
Coordinates 816360..816626 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV026_RS04170 811563..812996 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
DV026_RS04175 813115..813843 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
DV026_RS04180 813893..814204 + 312 WP_049116108.1 N(4)-acetylcytidine aminohydrolase -
DV026_RS04185 814367..815026 + 660 WP_004205319.1 hemolysin III family protein -
DV026_RS04190 815131..816114 - 984 WP_049116109.1 tRNA-modifying protein YgfZ -
DV026_RS04195 816360..816626 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DV026_RS04200 816607..817017 + 411 WP_004205323.1 protein YgfX Toxin
DV026_RS04205 817024..817545 - 522 WP_004205324.1 flavodoxin FldB -
DV026_RS04210 817646..818542 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DV026_RS04215 818565..819278 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DV026_RS04220 819284..821017 + 1734 WP_117984785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T108770 WP_004205323.1 NZ_CP031257:816607-817017 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T108770 NZ_CP031257:816607-817017 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT108770 WP_002916312.1 NZ_CP031257:816360-816626 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT108770 NZ_CP031257:816360-816626 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References