Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731458..732233 Replicon chromosome
Accession NZ_CP031257
Organism Klebsiella quasipneumoniae strain L22

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag DV026_RS03770 Protein ID WP_049092700.1
Coordinates 731748..732233 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag DV026_RS03765 Protein ID WP_049092701.1
Coordinates 731458..731751 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV026_RS03745 726661..727263 - 603 WP_049115637.1 short chain dehydrogenase -
DV026_RS03750 727361..728272 + 912 WP_117984770.1 LysR family transcriptional regulator -
DV026_RS03755 728273..729421 - 1149 WP_004205199.1 PLP-dependent aspartate aminotransferase family protein -
DV026_RS03760 729432..730808 - 1377 WP_072500772.1 cystathionine beta-synthase -
DV026_RS03765 731458..731751 + 294 WP_049092701.1 DUF1778 domain-containing protein Antitoxin
DV026_RS03770 731748..732233 + 486 WP_049092700.1 GNAT family N-acetyltransferase Toxin
DV026_RS03775 732412..732864 - 453 WP_049014234.1 hypothetical protein -
DV026_RS03780 732949..733197 - 249 WP_075205464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 725842..737406 11564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17471.39 Da        Isoelectric Point: 8.1467

>T108769 WP_049092700.1 NZ_CP031257:731748-732233 [Klebsiella quasipneumoniae]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMMLMVTLGDLVN
A

Download         Length: 486 bp

>T108769 NZ_CP031257:731748-732233 [Klebsiella quasipneumoniae]
ATGATCTCCGCTCCAGAACCGCTTCATACCGGGCATATTCTTACCCCGTTTTGTTGCGGCGTGGATTCTATGGATAACTG
GCTAAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCATCCCGCACGTTCGTCTGCTGTGACGATGCGAAGGTAATGG
CGTACTACTCGCTGGCTTCAAGTGCTGTGACGACAAATACTGCGCCCGGTCGCTTCCGTCGCAATATGCCTGACCCGATC
CCGGTTGTGGTGCTGGGACGTCTGGCGGTGGATAAATCGCTGCATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
TGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCTCGAG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCTATAGATCCGATGATGCTGATGGTGACATTGGGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10972.58 Da        Isoelectric Point: 8.6141

>AT108769 WP_049092701.1 NZ_CP031257:731458-731751 [Klebsiella quasipneumoniae]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT108769 NZ_CP031257:731458-731751 [Klebsiella quasipneumoniae]
ATGCCAGCCGCAAACAGTATGACGATGAAACGCGAAACCTTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGAGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATTATTTTGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGAGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References