Detailed information of TA system TA108766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4862230..4863050
• Replicon: chromosome
• Accession: NZ_CP031256
• Organism: Escherichia coli strain M16807

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: DV447_RS24990
• Protein ID: WP_001054379.1
• Coordinates: 4862230..4862487 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: DV447_RS24995
• Protein ID: WP_000123957.1
• Coordinates: 4862499..4863050 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV447_RS24965	4857777..4858757	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DV447_RS24970	4859340..4860446	-	1107	Protein_4541	helicase YjhR	-
DV447_RS24975	4860509..4861656	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
DV447_RS24980	4861689..4861853	+	165	Protein_4543	GNAT family N-acetyltransferase	-
DV447_RS24990	4862230..4862487	+	258	WP_001054379.1	YjhX family toxin	Toxin
DV447_RS24995	4862499..4863050	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
DV447_RS25000	4863102..4863848	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
DV447_RS25005	4863976..4864236	+	261	WP_000077645.1	hypothetical protein	-
DV447_RS26890	4864274..4864390	+	117	Protein_4548	VOC family protein	-
DV447_RS25010	4864635..4865756	+	1122	WP_000010833.1	M42 family metallopeptidase	-
DV447_RS25015	4865753..4866031	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DV447_RS25020	4866043..4867356	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4850848..4871271	20423

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T108766 WP_001054379.1 NZ_CP031256:4862230-4862487 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T108766 NZ_CP031256:4862230-4862487 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT108766 WP_000123957.1 NZ_CP031256:4862499-4863050 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT108766 NZ_CP031256:4862499-4863050 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030