Detailed information of TA system TA108738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2480471..2481126
• Replicon: chromosome
• Accession: NZ_CP031255
• Organism: Neisseria elongata strain M15910

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DV445_RS12620
• Protein ID: WP_114922575.1
• Coordinates: 2480707..2481126 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DV445_RS12615
• Protein ID: WP_114922574.1
• Coordinates: 2480471..2480710 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV445_RS13080	2475727..2476218	-	492	WP_162817677.1	hypothetical protein	-
DV445_RS12595	2477072..2477713	-	642	WP_162817678.1	XRE family transcriptional regulator	-
DV445_RS12600	2477832..2478044	+	213	WP_114922571.1	helix-turn-helix domain-containing protein	-
DV445_RS12605	2478047..2478820	+	774	WP_114922572.1	hypothetical protein	-
DV445_RS12610	2479332..2480027	-	696	WP_162817679.1	hypothetical protein	-
DV445_RS12615	2480471..2480710	+	240	WP_114922574.1	antitoxin	Antitoxin
DV445_RS12620	2480707..2481126	+	420	WP_114922575.1	type II toxin-antitoxin system VapC family toxin	Toxin
DV445_RS12625	2481221..2482303	-	1083	WP_114922576.1	traS protein	-
DV445_RS12630	2482387..2482908	-	522	WP_162817680.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2470789..2502911	32122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15321.74 Da
• Isoelectric Point: 8.4823

>T108738 WP_114922575.1 NZ_CP031255:2480707-2481126 [Neisseria elongata]
MILLDTNVVSEALRPEPSTKVISWLDEQVWETLYLSAITVAELRMGAAVLPDGRKKDLLVDRLENRIFPLFEGRILSFDE
PAAAVYAQIRSTARKQGKAVAAADGYIAATAKLHRMVVATRDVSPFRAAGVKVINPWSD

Nucleotide

• Length: 420 bp

>T108738 NZ_CP031255:2480707-2481126 [Neisseria elongata]
ATGATTTTGCTGGATACCAATGTTGTTTCAGAAGCGCTGCGTCCTGAGCCGTCTACCAAAGTCATTTCATGGCTGGACGA
ACAGGTTTGGGAAACGCTCTATTTGTCCGCCATTACGGTTGCGGAATTGCGGATGGGGGCTGCCGTATTGCCTGACGGCC
GCAAAAAGGATTTGCTGGTCGATCGTTTGGAAAACAGAATATTTCCGTTATTTGAAGGGCGGATTCTGTCTTTTGACGAG
CCGGCGGCGGCGGTTTATGCACAAATACGTTCGACCGCCCGCAAACAGGGCAAAGCGGTTGCCGCTGCAGACGGCTATAT
CGCGGCTACGGCAAAATTGCATAGAATGGTTGTGGCAACGCGGGACGTTTCTCCTTTCCGTGCGGCAGGAGTGAAGGTTA
TTAATCCGTGGTCGGATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8456.59 Da
• Isoelectric Point: 7.0138

>AT108738 WP_114922574.1 NZ_CP031255:2480471-2480710 [Neisseria elongata]
MASVLIRNLSDSTHNAIKSRARAAGRSTEAEIRLILDAAVQAKNPVRLGSLLAGIGREIGGVELEDVRDRSTGIEVNFE

Nucleotide

• Length: 240 bp

>AT108738 NZ_CP031255:2480471-2480710 [Neisseria elongata]
ATGGCATCCGTCCTCATCAGAAATCTGTCAGACAGCACCCACAACGCGATCAAATCCCGGGCACGGGCGGCCGGCCGCAG
CACAGAGGCTGAAATCCGCCTGATACTGGATGCCGCCGTACAGGCTAAAAATCCTGTTCGGTTAGGATCTCTTTTAGCTG
GGATAGGTAGGGAAATTGGCGGTGTGGAGTTGGAAGATGTCCGCGACAGATCAACAGGTATTGAAGTGAATTTCGAATGA