Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1776571..1777106 Replicon chromosome
Accession NZ_CP031254
Organism Haemophilus influenzae strain M25588

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DV401_RS09000 Protein ID WP_071163272.1
Coordinates 1776571..1776834 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DV401_RS09005 Protein ID WP_071163271.1
Coordinates 1776831..1777106 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV401_RS09340 1772268..1772441 - 174 WP_005657572.1 DUF5363 domain-containing protein -
DV401_RS08985 1772438..1774408 - 1971 WP_114877486.1 tRNA(Met) cytidine acetyltransferase TmcA -
DV401_RS08990 1774413..1774754 - 342 WP_040033872.1 SirB2 family protein -
DV401_RS08995 1774817..1776487 - 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
DV401_RS09000 1776571..1776834 - 264 WP_071163272.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DV401_RS09005 1776831..1777106 - 276 WP_071163271.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DV401_RS09010 1777457..1778077 + 621 WP_005650213.1 zinc transporter binding subunit ZevA -
DV401_RS09015 1778080..1779048 + 969 WP_071163270.1 zinc transporter permease subunit ZevB -
DV401_RS09025 1779663..1781702 + 2040 WP_071163269.1 excinuclease ABC subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T108737 WP_071163272.1 NZ_CP031254:c1776834-1776571 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLLINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T108737 NZ_CP031254:c1776834-1776571 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTCTTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTGGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10277.84 Da        Isoelectric Point: 6.0646

>AT108737 WP_071163271.1 NZ_CP031254:c1777106-1776831 [Haemophilus influenzae]
MAAVSFRVPDETKNMAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT108737 NZ_CP031254:c1777106-1776831 [Haemophilus influenzae]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATGGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCACTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References