Detailed information of TA system TA108735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 781200..781537
• Replicon: chromosome
• Accession: NZ_CP031254
• Organism: Haemophilus influenzae strain M25588

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: -
• Locus tag: DV401_RS03935
• Protein ID: WP_071162882.1
• Coordinates: 781400..781537 (+)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: -
• Locus tag: DV401_RS03930
• Protein ID: WP_114877262.1
• Coordinates: 781200..781391 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV401_RS03910	777409..778392	+	984	WP_071162884.1	DNA polymerase III subunit delta'	-
DV401_RS03915	778447..779229	+	783	WP_071162883.1	YchF/TatD family DNA exonuclease	-
DV401_RS03920	779256..779780	+	525	WP_005652096.1	DUF1523 family protein	-
DV401_RS03925	779831..781129	+	1299	Protein_732	HlyC/CorC family transporter	-
DV401_RS03930	781200..781391	+	192	WP_114877262.1	DUF5397 family protein	Antitoxin
DV401_RS03935	781400..781537	+	138	WP_071162882.1	virulence-associated protein D	Toxin
DV401_RS03940	781630..782160	+	531	WP_005686915.1	hypothetical protein	-
DV401_RS03945	782232..783731	+	1500	WP_071162881.1	fused PTS fructose transporter subunit IIA/HPr protein	-
DV401_RS03950	783733..784674	+	942	WP_071162880.1	1-phosphofructokinase	-
DV401_RS03955	784676..786346	+	1671	WP_071162879.1	fructose-specific PTS transporter subunit EIIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Protein of unknown function DUF5397 (1-63)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 5270.90 Da
• Isoelectric Point: 4.2907

>T108735 WP_071162882.1 NZ_CP031254:781400-781537 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAFLIEQWSNFTDFIRN

Nucleotide

• Length: 138 bp

>T108735 NZ_CP031254:781400-781537 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCTTTTCTTATTGAGCAATGGTCTAATTTTACTGATTTTATACGAAATTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7075.08 Da
• Isoelectric Point: 3.9930

>AT108735 WP_114877262.1 NZ_CP031254:781200-781391 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVVEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Nucleotide

• Length: 192 bp

>AT108735 NZ_CP031254:781200-781391 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGTGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA