Detailed information of TA system TA108732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 530077..530681
• Replicon: chromosome
• Accession: NZ_CP031254
• Organism: Haemophilus influenzae strain M25588

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DV401_RS02640
• Protein ID: WP_103708038.1
• Coordinates: 530077..530385 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: DV401_RS02645
• Protein ID: WP_005661259.1
• Coordinates: 530385..530681 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV401_RS02630	525179..526477	-	1299	WP_103708036.1	trigger factor	-
DV401_RS02635	526778..530020	+	3243	WP_112066908.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV401_RS02640	530077..530385	-	309	WP_103708038.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DV401_RS02645	530385..530681	-	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DV401_RS02650	530801..530926	-	126	WP_005654327.1	hypothetical protein	-
DV401_RS02655	530910..532769	-	1860	WP_103708039.1	selenocysteine-specific translation elongation factor	-
DV401_RS02660	532766..534151	-	1386	WP_071162996.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11867.58 Da
• Isoelectric Point: 6.8594

>T108732 WP_103708038.1 NZ_CP031254:c530385-530077 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYQDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T108732 NZ_CP031254:c530385-530077 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCAAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACTGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT108732 WP_005661259.1 NZ_CP031254:c530681-530385 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT108732 NZ_CP031254:c530681-530385 [Haemophilus influenzae]
ATGGCACTTACTAATTCCTCTATCAGTTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2