Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1114002..1114657 Replicon chromosome
Accession NZ_CP031253
Organism Neisseria lactamica strain M17106

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DV311_RS06185 Protein ID WP_114935481.1
Coordinates 1114002..1114421 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DV311_RS06190 Protein ID WP_114935482.1
Coordinates 1114421..1114657 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV311_RS06165 1109235..1110641 - 1407 WP_114936089.1 MFS transporter -
DV311_RS06170 1110925..1111704 + 780 WP_114935480.1 (Fe-S)-binding protein -
DV311_RS06175 1111701..1112402 + 702 WP_003709033.1 lactate utilization protein C -
DV311_RS06180 1112399..1113853 + 1455 WP_003709031.1 iron-sulfur cluster-binding protein -
DV311_RS06185 1114002..1114421 - 420 WP_114935481.1 type II toxin-antitoxin system toxin FitB Toxin
DV311_RS06190 1114421..1114657 - 237 WP_114935482.1 antitoxin Antitoxin
DV311_RS06195 1114912..1115354 + 443 Protein_1103 DNA cytosine methyltransferase -
DV311_RS06205 1115471..1115956 - 486 WP_096108854.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DV311_RS06210 1116005..1116718 - 714 WP_114935483.1 tol-pal system YbgF family protein -
DV311_RS06215 1116718..1117386 - 669 WP_002239889.1 O-methyltransferase -
DV311_RS06220 1117397..1117582 - 186 WP_114935484.1 DUF3460 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15338.74 Da        Isoelectric Point: 6.2277

>T108731 WP_114935481.1 NZ_CP031253:c1114421-1114002 [Neisseria lactamica]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLPDGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKAIAAADGYIAATAKQHRLTVATRDTGPFFAADVAVFNPWYD

Download         Length: 420 bp

>T108731 NZ_CP031253:c1114421-1114002 [Neisseria lactamica]
ATGATTTTACTGGATACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCCTGATGGTA
AGAAAAAGAATGTGCTGCACGAGCGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGCGATTGCCGCCGCAGACGGCTATAT
TGCAGCAACGGCCAAACAGCACCGTTTGACAGTTGCTACGCGTGATACCGGCCCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGTACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8517.64 Da        Isoelectric Point: 7.0122

>AT108731 WP_114935482.1 NZ_CP031253:c1114657-1114421 [Neisseria lactamica]
MASVVIRNLSESTHNALKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEVGGVELDNVRDFDTKNEVSF

Download         Length: 237 bp

>AT108731 NZ_CP031253:c1114657-1114421 [Neisseria lactamica]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGAGCACGCACAACGCACTCAAATTCCGCGCGCGAGCTGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATCTTGGATAACATCGCCAAAGCACAGCAAACGGTACGCTTGGGGTCAATGTTGGCAT
CAATCGGGCAGGAAGTAGGCGGGGTGGAATTGGATAACGTGCGTGATTTCGATACCAAGAATGAGGTATCCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References