Detailed information of TA system TA108728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 498172..498643
• Replicon: chromosome
• Accession: NZ_CP031250
• Organism: Haemophilus influenzae strain M21384

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: DV389_RS02465
• Protein ID: WP_005654546.1
• Coordinates: 498172..498354 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV389_RS02470
• Protein ID: WP_005650837.1
• Coordinates: 498347..498643 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV389_RS02460	494999..497902	+	2904	WP_114893027.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV389_RS02465	498172..498354	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
DV389_RS02470	498347..498643	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV389_RS02475	498810..500726	+	1917	WP_114893028.1	ABC transporter ATP-binding protein	-
DV389_RS02480	500736..501272	+	537	WP_114893029.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV389_RS02485	501288..501839	+	552	WP_114893030.1	Sua5/YciO/YrdC/YwlC family protein	-
DV389_RS02490	501843..502649	+	807	WP_114893031.1	shikimate dehydrogenase	-
DV389_RS02495	502661..503413	+	753	WP_105881307.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T108728 WP_005654546.1 NZ_CP031250:498172-498354 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T108728 NZ_CP031250:498172-498354 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108728 WP_005650837.1 NZ_CP031250:498347-498643 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108728 NZ_CP031250:498347-498643 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9