Detailed information of TA system TA108725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1030666..1031303
• Replicon: chromosome
• Accession: NZ_CP031249
• Organism: Haemophilus influenzae strain M15895

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: A0A8G1T738
• Locus tag: DV378_RS05130
• Protein ID: WP_050948994.1
• Coordinates: 1030899..1031303 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A0A0H3PN67
• Locus tag: DV378_RS05125
• Protein ID: WP_005656316.1
• Coordinates: 1030666..1030902 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV378_RS05100	1026043..1026783	-	741	WP_005662961.1	YebC/PmpR family DNA-binding transcriptional regulator	-
DV378_RS05105	1026796..1027269	-	474	WP_050948992.1	dihydroneopterin triphosphate diphosphatase	-
DV378_RS05110	1027291..1029057	-	1767	WP_050948993.1	aspartate--tRNA ligase	-
DV378_RS05115	1029276..1029794	+	519	WP_005688985.1	isoprenylcysteine carboxyl methyltransferase family protein	-
DV378_RS05120	1029848..1030573	+	726	WP_021035687.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
DV378_RS05125	1030666..1030902	+	237	WP_005656316.1	antitoxin	Antitoxin
DV378_RS05130	1030899..1031303	+	405	WP_050948994.1	type II toxin-antitoxin system VapC family toxin	Toxin
DV378_RS05135	1031370..1031777	+	408	WP_005688980.1	lactoylglutathione lyase	-
DV378_RS05140	1031851..1032540	+	690	WP_021035684.1	ribonuclease T	-
DV378_RS05145	1032854..1034206	+	1353	WP_050948995.1	Na+/H+ antiporter family protein	-
DV378_RS05150	1034238..1034822	+	585	WP_114934783.1	primosomal replication protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15676.23 Da
• Isoelectric Point: 8.9777

>T108725 WP_050948994.1 NZ_CP031249:1030899-1031303 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRVTDLQWQDWTK

Nucleotide

• Length: 405 bp

>T108725 NZ_CP031249:1030899-1031303 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTGTTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9007.16 Da
• Isoelectric Point: 4.2342

>AT108725 WP_005656316.1 NZ_CP031249:1030666-1030902 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT108725 NZ_CP031249:1030666-1030902 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3PN67