Detailed information of TA system TA108724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 683719..684193
• Replicon: chromosome
• Accession: NZ_CP031249
• Organism: Haemophilus influenzae strain M15895

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: -
• Locus tag: DV378_RS03320
• Protein ID: WP_197733310.1
• Coordinates: 683719..683904 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV378_RS03325
• Protein ID: WP_005650837.1
• Coordinates: 683897..684193 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV378_RS03315	680582..683576	+	2995	Protein_647	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV378_RS03320	683719..683904	+	186	WP_197733310.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV378_RS03325	683897..684193	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV378_RS03330	684377..686293	+	1917	WP_050949050.1	ABC transporter ATP-binding protein	-
DV378_RS03335	686303..686839	+	537	WP_050949051.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV378_RS03340	686855..687406	+	552	WP_050949052.1	Sua5/YciO/YrdC/YwlC family protein	-
DV378_RS03345	687410..688228	+	819	WP_050949053.1	shikimate dehydrogenase	-
DV378_RS03350	688225..688782	+	558	WP_050949054.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-51)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7462.80 Da
• Isoelectric Point: 11.0200

>T108724 WP_197733310.1 NZ_CP031249:683719-683904 [Haemophilus influenzae]
ILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 186 bp

>T108724 NZ_CP031249:683719-683904 [Haemophilus influenzae]
ATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGT
CTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACAACGCTTAAGTGAAT
TAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108724 WP_005650837.1 NZ_CP031249:683897-684193 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108724 NZ_CP031249:683897-684193 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCCTTGGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA