Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 600128..600732 Replicon chromosome
Accession NZ_CP031249
Organism Haemophilus influenzae strain M15895

Toxin (Protein)


Gene name relE Uniprot ID A0A0K9L7B7
Locus tag DV378_RS02925 Protein ID WP_005692344.1
Coordinates 600424..600732 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag DV378_RS02920 Protein ID WP_005692346.1
Coordinates 600128..600424 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV378_RS02905 595894..597279 + 1386 WP_114934752.1 L-seryl-tRNA(Sec) selenium transferase -
DV378_RS02910 597276..599135 + 1860 WP_114934753.1 selenocysteine-specific translation elongation factor -
DV378_RS02915 599154..600008 + 855 WP_112088318.1 DUF3298 domain-containing protein -
DV378_RS02920 600128..600424 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DV378_RS02925 600424..600732 + 309 WP_005692344.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DV378_RS02930 600789..604108 - 3320 Protein_573 TonB-dependent receptor -
DV378_RS02935 604408..605706 + 1299 WP_114934754.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hgpC / hgpC 594395..604108 9713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11974.77 Da        Isoelectric Point: 8.4339

>T108722 WP_005692344.1 NZ_CP031249:600424-600732 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGNLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T108722 NZ_CP031249:600424-600732 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTGCCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCTATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT108722 WP_005692346.1 NZ_CP031249:600128-600424 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT108722 NZ_CP031249:600128-600424 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L7B7

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References