Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 534794..535272 Replicon chromosome
Accession NZ_CP031249
Organism Haemophilus influenzae strain M15895

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag DV378_RS02625 Protein ID WP_050848517.1
Coordinates 534794..535072 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag DV378_RS02630 Protein ID WP_012055040.1
Coordinates 535081..535272 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV378_RS02605 529982..531652 - 1671 WP_050948743.1 fructose-specific PTS transporter subunit EIIC -
DV378_RS02610 531654..532595 - 942 WP_050948744.1 1-phosphofructokinase -
DV378_RS02615 532597..534096 - 1500 WP_050948745.1 fused PTS fructose transporter subunit IIA/HPr protein -
DV378_RS02620 534168..534698 - 531 WP_050948746.1 hypothetical protein -
DV378_RS02625 534794..535072 - 279 WP_050848517.1 virulence-associated protein VapD Toxin
DV378_RS02630 535081..535272 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
DV378_RS02635 535343..536641 - 1299 WP_050948747.1 hemolysin family protein -
DV378_RS02640 536692..537216 - 525 WP_050948748.1 DUF1523 family protein -
DV378_RS02645 537243..538025 - 783 WP_050948749.1 YchF/TatD family DNA exonuclease -
DV378_RS02650 538064..539044 - 981 WP_050948750.1 DNA polymerase III subunit delta' -
DV378_RS02655 539041..539673 - 633 WP_050948790.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T108721 WP_050848517.1 NZ_CP031249:c535072-534794 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

>T108721 NZ_CP031249:c535072-534794 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATTCGCTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT108721 WP_012055040.1 NZ_CP031249:c535272-535081 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT108721 NZ_CP031249:c535272-535081 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACGGGCTGTATTAAACAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References