Detailed information of TA system TA108720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 17673..18208
• Replicon: chromosome
• Accession: NZ_CP031249
• Organism: Haemophilus influenzae strain M15895

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A852PXV4
• Locus tag: DV378_RS00060
• Protein ID: WP_061671384.1
• Coordinates: 17673..17936 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G1T6U5
• Locus tag: DV378_RS00065
• Protein ID: WP_050948473.1
• Coordinates: 17933..18208 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV378_RS09595	13361..13534	-	174	WP_005657572.1	DUF5363 domain-containing protein	-
DV378_RS00045	13531..15501	-	1971	WP_050948471.1	tRNA(Met) cytidine acetyltransferase TmcA	-
DV378_RS00050	15506..15847	-	342	WP_050846956.1	SirB2 family protein	-
DV378_RS00055	15909..17579	-	1671	WP_050848571.1	energy-dependent translational throttle protein EttA	-
DV378_RS00060	17673..17936	-	264	WP_061671384.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DV378_RS00065	17933..18208	-	276	WP_050948473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DV378_RS00070	18560..19180	+	621	WP_050846950.1	zinc transporter binding subunit ZevA	-
DV378_RS00075	19183..20157	+	975	WP_114934723.1	zinc transporter permease subunit ZevB	-
DV378_RS00080	20333..20974	-	642	Protein_16	ESPR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10215.93 Da
• Isoelectric Point: 7.8978

>T108720 WP_061671384.1 NZ_CP031249:c17936-17673 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THSEIFG

Nucleotide

• Length: 264 bp

>T108720 NZ_CP031249:c17936-17673 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGTT
GGCGAGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGACTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10271.82 Da
• Isoelectric Point: 5.6663

>AT108720 WP_050948473.1 NZ_CP031249:c18208-17933 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKS

Nucleotide

• Length: 276 bp

>AT108720 NZ_CP031249:c18208-17933 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATAATGGGCGTGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTATCGGAGATGAAATCATGA

Structures

Toxin

• AlphaFold DB: A0A852PXV4