Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1989734..1990402 Replicon chromosome
Accession NZ_CP031248
Organism Streptococcus pneumoniae strain M26365

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag DV130_RS10875 Protein ID WP_001132282.1
Coordinates 1989734..1989913 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A654UAG7
Locus tag DV130_RS10880 Protein ID WP_050072377.1
Coordinates 1989950..1990402 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV130_RS10835 1985742..1985924 + 183 WP_050072381.1 DUF3173 domain-containing protein -
DV130_RS10840 1985926..1987053 + 1128 WP_050114860.1 site-specific integrase -
DV130_RS10850 1987473..1988744 - 1272 WP_050072379.1 replication-associated recombination protein A -
DV130_RS10860 1989014..1989253 + 240 WP_050072378.1 hypothetical protein -
DV130_RS10870 1989418..1989597 + 180 WP_001048906.1 hypothetical protein -
DV130_RS10875 1989734..1989913 + 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
DV130_RS10880 1989950..1990402 + 453 WP_050072377.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DV130_RS10885 1990693..1991163 + 471 WP_000257100.1 DUF3013 family protein -
DV130_RS10890 1991182..1992249 + 1068 WP_050072376.1 M50 family metallopeptidase -
DV130_RS10895 1992251..1992679 + 429 WP_050072375.1 NUDIX hydrolase -
DV130_RS10900 1992676..1993192 + 517 Protein_2015 GNAT family N-acetyltransferase -
DV130_RS10905 1993328..1994278 + 951 WP_050072374.1 50S ribosomal protein L11 methyltransferase -
DV130_RS10910 1994280..1995023 + 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-115)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T108719 WP_001132282.1 NZ_CP031248:1989734-1989913 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T108719 NZ_CP031248:1989734-1989913 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16645.43 Da        Isoelectric Point: 3.7220

>AT108719 WP_050072377.1 NZ_CP031248:1989950-1990402 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFVSMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT108719 NZ_CP031248:1989950-1990402 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTGTTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
AlphaFold DB A0A654UAG7

References