Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 294861..295359 Replicon chromosome
Accession NZ_CP031248
Organism Streptococcus pneumoniae strain M26365

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag DV130_RS01575 Protein ID WP_001823540.1
Coordinates 295105..295359 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DV130_RS01570 Protein ID WP_000208080.1
Coordinates 294861..295103 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV130_RS01550 290683..291858 + 1176 WP_000886145.1 A/G-specific adenine glycosylase -
DV130_RS01555 291913..292617 + 705 WP_000722076.1 response regulator transcription factor -
DV130_RS01560 292610..293959 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
DV130_RS01565 293961..294770 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
DV130_RS01570 294861..295103 + 243 WP_000208080.1 hypothetical protein Antitoxin
DV130_RS01575 295105..295359 + 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV130_RS01580 295406..296179 + 774 WP_050072391.1 ion transporter -
DV130_RS01585 296442..297428 - 987 WP_000204727.1 L-lactate dehydrogenase -
DV130_RS01590 297622..300090 + 2469 WP_001152989.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T108717 WP_001823540.1 NZ_CP031248:295105-295359 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T108717 NZ_CP031248:295105-295359 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT108717 WP_000208080.1 NZ_CP031248:294861-295103 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT108717 NZ_CP031248:294861-295103 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References