Detailed information of TA system TA108715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 377609..378855
• Replicon: chromosome
• Accession: NZ_CP031247
• Organism: Streptococcus pneumoniae strain M23734

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: DV129_RS02055
• Protein ID: WP_000405380.1
• Coordinates: 377609..378379 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DV129_RS02060
• Protein ID: WP_000579600.1
• Coordinates: 378379..378855 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV129_RS02025	373616..373981	-	366	WP_000401235.1	plasmid mobilization relaxosome protein MobC	-
DV129_RS02030	373986..374342	-	357	WP_000817506.1	hypothetical protein	-
DV129_RS02035	374638..374928	-	291	WP_001080184.1	hypothetical protein	-
DV129_RS02040	374918..375283	-	366	WP_000981955.1	hypothetical protein	-
DV129_RS02045	375280..376695	-	1416	WP_000118334.1	Y-family DNA polymerase	-
DV129_RS02050	376698..377381	-	684	WP_000492697.1	LexA family transcriptional regulator	-
DV129_RS02055	377609..378379	-	771	WP_000405380.1	zeta toxin family protein	Toxin
DV129_RS02060	378379..378855	-	477	WP_000579600.1	helix-turn-helix domain-containing protein	Antitoxin
DV129_RS02065	378925..379197	-	273	WP_000494368.1	hypothetical protein	-
DV129_RS02070	379235..379618	-	384	WP_000159221.1	hypothetical protein	-
DV129_RS02075	379615..379848	-	234	WP_000152419.1	hypothetical protein	-
DV129_RS02080	379899..380984	-	1086	WP_000401896.1	toprim domain-containing protein	-
DV129_RS02085	380994..381635	-	642	WP_000933085.1	hypothetical protein	-
DV129_RS02090	381795..381992	+	198	WP_001847545.1	hypothetical protein	-
DV129_RS02095	382006..382302	-	297	WP_000998899.1	hypothetical protein	-
DV129_RS02100	382316..382600	-	285	WP_000969643.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	337246..435769	98523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29363.25 Da
• Isoelectric Point: 7.1864

>T108715 WP_000405380.1 NZ_CP031247:c378379-377609 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALTRNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPRYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSKGYEVQLALIATKPELSYLSTLIRYEE
LYSINPNQARATSKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGL

Nucleotide

• Length: 771 bp

>T108715 NZ_CP031247:c378379-377609 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAACACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAAACTACAATTCATCGGATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACGCTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCTTTAATCGCAACCAAGCCCGAATTGTCCTATCTGAGTACTCTTATCCGATACGAAGAA
CTGTACTCTATCAATCCAAATCAAGCACGCGCAACTTCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTTGTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18257.65 Da
• Isoelectric Point: 4.4899

>AT108715 WP_000579600.1 NZ_CP031247:c378855-378379 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT108715 NZ_CP031247:c378855-378379 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGACTTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGGTATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA