Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 377609..378855 Replicon chromosome
Accession NZ_CP031247
Organism Streptococcus pneumoniae strain M23734

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag DV129_RS02055 Protein ID WP_000405380.1
Coordinates 377609..378379 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DV129_RS02060 Protein ID WP_000579600.1
Coordinates 378379..378855 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV129_RS02025 373616..373981 - 366 WP_000401235.1 plasmid mobilization relaxosome protein MobC -
DV129_RS02030 373986..374342 - 357 WP_000817506.1 hypothetical protein -
DV129_RS02035 374638..374928 - 291 WP_001080184.1 hypothetical protein -
DV129_RS02040 374918..375283 - 366 WP_000981955.1 hypothetical protein -
DV129_RS02045 375280..376695 - 1416 WP_000118334.1 Y-family DNA polymerase -
DV129_RS02050 376698..377381 - 684 WP_000492697.1 LexA family transcriptional regulator -
DV129_RS02055 377609..378379 - 771 WP_000405380.1 zeta toxin family protein Toxin
DV129_RS02060 378379..378855 - 477 WP_000579600.1 helix-turn-helix domain-containing protein Antitoxin
DV129_RS02065 378925..379197 - 273 WP_000494368.1 hypothetical protein -
DV129_RS02070 379235..379618 - 384 WP_000159221.1 hypothetical protein -
DV129_RS02075 379615..379848 - 234 WP_000152419.1 hypothetical protein -
DV129_RS02080 379899..380984 - 1086 WP_000401896.1 toprim domain-containing protein -
DV129_RS02085 380994..381635 - 642 WP_000933085.1 hypothetical protein -
DV129_RS02090 381795..381992 + 198 WP_001847545.1 hypothetical protein -
DV129_RS02095 382006..382302 - 297 WP_000998899.1 hypothetical protein -
DV129_RS02100 382316..382600 - 285 WP_000969643.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) - 337246..435769 98523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29363.25 Da        Isoelectric Point: 7.1864

>T108715 WP_000405380.1 NZ_CP031247:c378379-377609 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALTRNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPRYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSKGYEVQLALIATKPELSYLSTLIRYEE
LYSINPNQARATSKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGL

Download         Length: 771 bp

>T108715 NZ_CP031247:c378379-377609 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAACACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAAACTACAATTCATCGGATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACGCTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCTTTAATCGCAACCAAGCCCGAATTGTCCTATCTGAGTACTCTTATCCGATACGAAGAA
CTGTACTCTATCAATCCAAATCAAGCACGCGCAACTTCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGGCAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTTGTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18257.65 Da        Isoelectric Point: 4.4899

>AT108715 WP_000579600.1 NZ_CP031247:c378855-378379 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT108715 NZ_CP031247:c378855-378379 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGACTTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGGTATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References