Detailed information of TA system TA108714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 306448..306946
• Replicon: chromosome
• Accession: NZ_CP031247
• Organism: Streptococcus pneumoniae strain M23734

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1CEI0
• Locus tag: DV129_RS01705
• Protein ID: WP_001823540.1
• Coordinates: 306692..306946 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DV129_RS01700
• Protein ID: WP_012677101.1
• Coordinates: 306448..306690 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV129_RS01680	302269..303444	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
DV129_RS01685	303500..304204	+	705	WP_000722076.1	response regulator transcription factor	-
DV129_RS01690	304197..305546	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
DV129_RS01695	305548..306357	+	810	WP_114865959.1	MBL fold metallo-hydrolase	-
DV129_RS01700	306448..306690	+	243	WP_012677101.1	hypothetical protein	Antitoxin
DV129_RS01705	306692..306946	+	255	WP_001823540.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV129_RS01710	306993..307736	+	744	WP_000725952.1	ion transporter	-
DV129_RS01715	308026..309012	-	987	WP_000204727.1	L-lactate dehydrogenase	-
DV129_RS01720	309206..311674	+	2469	WP_001152988.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10040.76 Da
• Isoelectric Point: 10.9371

>T108714 WP_001823540.1 NZ_CP031247:306692-306946 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T108714 NZ_CP031247:306692-306946 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9204.47 Da
• Isoelectric Point: 4.1051

>AT108714 WP_012677101.1 NZ_CP031247:306448-306690 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVANLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT108714 NZ_CP031247:306448-306690 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAAATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Toxin

• AlphaFold DB: C1CEI0