Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 91514..92182 Replicon chromosome
Accession NZ_CP031246
Organism Streptococcus pneumoniae strain M26368

Toxin (Protein)


Gene name hicA Uniprot ID G0ICE6
Locus tag DV131_RS00485 Protein ID WP_001132281.1
Coordinates 92003..92182 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DV131_RS00480 Protein ID WP_000961810.1
Coordinates 91514..91966 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV131_RS00460 88363..89397 - 1035 WP_000747915.1 ATP-binding protein -
DV131_RS00465 89507..89665 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
DV131_RS00470 89646..90734 - 1089 WP_000719719.1 M50 family metallopeptidase -
DV131_RS00475 90753..91223 - 471 WP_000257097.1 DUF3013 family protein -
DV131_RS00480 91514..91966 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DV131_RS00485 92003..92182 - 180 WP_001132281.1 type II toxin-antitoxin system HicA family toxin Toxin
DV131_RS00490 92319..92507 - 189 WP_001833848.1 hypothetical protein -
DV131_RS00495 92662..92901 - 240 WP_000818079.1 hypothetical protein -
DV131_RS00505 93171..94442 + 1272 WP_001113214.1 replication-associated recombination protein A -
DV131_RS00515 94989..96308 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 60177..94442 34265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6677.88 Da        Isoelectric Point: 11.0174

>T108711 WP_001132281.1 NZ_CP031246:c92182-92003 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T108711 NZ_CP031246:c92182-92003 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT108711 WP_000961810.1 NZ_CP031246:c91966-91514 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT108711 NZ_CP031246:c91966-91514 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0ICE6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References