Detailed information of TA system TA108709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1662490..1662988
• Replicon: chromosome
• Accession: NZ_CP031245
• Organism: Streptococcus pneumoniae strain M16808

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DV119_RS08950
• Protein ID: WP_001812387.1
• Coordinates: 1662490..1662744 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: DV119_RS08955
• Protein ID: WP_000208080.1
• Coordinates: 1662746..1662988 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV119_RS08935	1657759..1660227	-	2469	WP_001152989.1	DNA gyrase subunit A	-
DV119_RS08940	1660421..1661407	+	987	WP_000204727.1	L-lactate dehydrogenase	-
DV119_RS08945	1661670..1662443	-	774	WP_044811410.1	ion transporter	-
DV119_RS08950	1662490..1662744	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV119_RS08955	1662746..1662988	-	243	WP_000208080.1	hypothetical protein	Antitoxin
DV119_RS08960	1663079..1663888	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
DV119_RS08965	1663890..1665239	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
DV119_RS08970	1665232..1665936	-	705	WP_000722076.1	response regulator transcription factor	-
DV119_RS08975	1665991..1667166	-	1176	WP_000886125.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T108709 WP_001812387.1 NZ_CP031245:c1662744-1662490 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T108709 NZ_CP031245:c1662744-1662490 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT108709 WP_000208080.1 NZ_CP031245:c1662988-1662746 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT108709 NZ_CP031245:c1662988-1662746 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7