Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 60939..61601 Replicon chromosome
Accession NZ_CP031245
Organism Streptococcus pneumoniae strain M16808

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DV119_RS00355 Protein ID WP_172592534.1
Coordinates 61428..61601 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DV119_RS00350 Protein ID WP_000961810.1
Coordinates 60939..61391 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV119_RS00320 56318..57061 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
DV119_RS00325 57063..58013 - 951 WP_050072374.1 50S ribosomal protein L11 methyltransferase -
DV119_RS00330 58149..58665 - 517 Protein_62 GNAT family N-acetyltransferase -
DV119_RS00335 58662..59090 - 429 WP_050072375.1 NUDIX hydrolase -
DV119_RS00340 59092..60159 - 1068 WP_000719721.1 M50 family metallopeptidase -
DV119_RS00345 60178..60648 - 471 WP_054387465.1 DUF3013 family protein -
DV119_RS00350 60939..61391 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DV119_RS00355 61428..61601 - 174 WP_172592534.1 type II toxin-antitoxin system HicA family toxin Toxin
DV119_RS00360 61744..61923 - 180 WP_001809903.1 hypothetical protein -
DV119_RS00370 62088..62327 - 240 WP_000818078.1 hypothetical protein -
DV119_RS00380 62597..63868 + 1272 WP_054387466.1 replication-associated recombination protein A -
DV119_RS00390 64413..65732 - 1320 WP_000502560.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6396.53 Da        Isoelectric Point: 10.8214

>T108707 WP_172592534.1 NZ_CP031245:c61601-61428 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQVGL

Download         Length: 174 bp

>T108707 NZ_CP031245:c61601-61428 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCTCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGTTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT108707 WP_000961810.1 NZ_CP031245:c61391-60939 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT108707 NZ_CP031245:c61391-60939 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References