Detailed information of TA system TA108706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1408855..1410413
• Replicon: chromosome
• Accession: NZ_CP031243
• Organism: Haemophilus haemolyticus strain M19346

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DV428_RS06920
• Protein ID: WP_114909589.1
• Coordinates: 1409133..1410413 (+)
• Length: 427 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: F9GPT1
• Locus tag: DV428_RS06915
• Protein ID: WP_005631862.1
• Coordinates: 1408855..1409133 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV428_RS06890	1404230..1405456	+	1227	WP_005629305.1	Ni/Fe-hydrogenase cytochrome b subunit	-
DV428_RS06895	1405456..1407165	+	1710	WP_114909173.1	hydrogenase 2 large subunit	-
DV428_RS06900	1407165..1407638	+	474	WP_114909174.1	HyaD/HybD family hydrogenase maturation endopeptidase	-
DV428_RS06905	1407730..1408239	+	510	WP_114909175.1	hydrogenase-2 assembly chaperone	-
DV428_RS06910	1408269..1408544	+	276	WP_005626486.1	hydrogenase maturation factor HybG	-
DV428_RS06915	1408855..1409133	+	279	WP_005631862.1	helix-turn-helix domain-containing protein	Antitoxin
DV428_RS06920	1409133..1410413	+	1281	WP_114909589.1	type II toxin-antitoxin system HipA family toxin	Toxin
DV428_RS06925	1410455..1411306	-	852	WP_114909176.1	hypothetical protein	-
DV428_RS06930	1411352..1414216	-	2865	WP_114909177.1	valine--tRNA ligase	-
DV428_RS06935	1414234..1414536	-	303	WP_114909178.1	hypothetical protein	-
DV428_RS06940	1414546..1414869	-	324	WP_114909179.1	N(4)-acetylcytidine aminohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 427 a.a.
• Molecular weight: 49132.43 Da
• Isoelectric Point: 7.5029

>T108706 WP_114909589.1 NZ_CP031243:1409133-1410413 [Haemophilus haemolyticus]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLKNYHTFPLGMEEREDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKALGLSVPQSQIHYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMTWHGENKHYLWDKIQLRHIFNTAKLAGLAKETVEDILHEICALYPRVSE
INTHGLPDEIVEPILMGLEMQMKKIS

Nucleotide

• Length: 1281 bp

>T108706 NZ_CP031243:1409133-1410413 [Haemophilus haemolyticus]
ATGAGTAACTCGATTCTAAACGTTGCCATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGCGCCACCGA
ATTTCAGTATGCGGAAAAATGGCTTGAATCTGTTCGCTCGCGTCCTATTTCATTGTCACTGCCCTTGTCGCACAAAATTT
ATCGAGGAGATTCCGTTTACAATTTCTTCGATAATCTCCTCCCGGACAATGAGCAGATCCGTTCACGCATTCAACAACGT
TTCCAAACCTCAACGAAATCCCCATTTGATTTACTTTCGGCGATTGGACAGGATTGTATCGGCGCAATTCAACTTTATCA
GGGCGAGAACCGCTCGGTACGTCAAATTTATGCAGAACCGCTAAATGACAAAGAGGTGGAAAACGTGCTGAAAAACTACC
ACACTTTTCCTCTAGGCATGGAAGAACGCGAGGATTTCCGAATTTCTTTAGCCGGCGCTCAGGAAAAAACAGCGCTGCTT
TATTATCAGAATCAATGGCAGCGCCCTTTGCATTCCACCGCGACCAGCCATATTTTTAAACTCCCGATTGGTATGGTCGC
ACAAGGGCAGCTTGATCTTTCCGGCAGCTGTGAAAATGAATGGCTTTGCTTGAATATCATGAAAGCCCTCGGTTTATCGG
TTCCTCAAAGCCAAATTCATTATTTCGGTGAAATGAAAGTACTGATTGTGGAGCGCTTTGATCGTCGTTGGTCTGAAAAT
AGGAGTTGGCTAATTCGTTTACCACAAGAAGATATGTGCCAAGCACTCAACATCGCTCCTGCACGAAAATATGAAAATGA
CGGTGGTCCGAGCATTCTGCAAATTATGTCGCTCCTCAACGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTTA
AAGCACAAATTATTTTCTGGCTACTTTGTGCCATTGACGGTCATGGCAAAAACTTCAGTTTATTTTTGGAACAAGAGAAT
CGCTATCGTCTAACGCCTTTTTATGATGTGATGTCCGCCTATCCGCTCATCAAACACAACGGACTACAAAAGCAAAAAGT
CAAAATGGCAATGACGTGGCACGGCGAAAATAAACATTATTTATGGGATAAAATACAACTCCGCCACATTTTTAATACGG
CTAAACTCGCCGGCCTAGCAAAGGAAACGGTAGAAGACATTTTGCATGAGATCTGTGCACTATATCCAAGAGTAAGTGAA
ATAAATACCCATGGATTACCTGATGAAATTGTTGAGCCTATTTTAATGGGATTAGAAATGCAGATGAAAAAGATAAGTTA
A

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10371.81 Da
• Isoelectric Point: 4.8483

>AT108706 WP_005631862.1 NZ_CP031243:1408855-1409133 [Haemophilus haemolyticus]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTALSIK
EPTATYDDDEAW

Nucleotide

• Length: 279 bp

>AT108706 NZ_CP031243:1408855-1409133 [Haemophilus haemolyticus]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTCATTCGTGAATTTCGCTATCAAGGCGATCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACTACCCAAGCCAGAATTTCAGCGTTTGAGAATGAGCCAGAGCGTACTAAATTAGAAACGCTAT
TTAAAATTCTAGCAGGATTAGAACTAGAGCTTATTGTGCAACCACGCAAAAAGTCATCTGATACTGCTCTCTCAATCAAG
GAGCCAACAGCAACATACGATGACGACGAGGCATGGTAA

Structures

Antitoxin

• AlphaFold DB: F9GPT1