Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1307078..1307556 Replicon chromosome
Accession NZ_CP031242
Organism Haemophilus influenzae strain M21460

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag DV390_RS06475 Protein ID WP_011272058.1
Coordinates 1307278..1307556 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag DV390_RS06470 Protein ID WP_011272059.1
Coordinates 1307078..1307269 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV390_RS06450 1303286..1304269 + 984 WP_011272062.1 DNA polymerase III subunit delta' -
DV390_RS06455 1304324..1305106 + 783 WP_011272061.1 YchF/TatD family DNA exonuclease -
DV390_RS06460 1305133..1305657 + 525 WP_011272060.1 DUF1523 family protein -
DV390_RS06465 1305708..1307006 + 1299 WP_005691371.1 hemolysin family protein -
DV390_RS06470 1307078..1307269 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
DV390_RS06475 1307278..1307556 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
DV390_RS06480 1307649..1308179 + 531 WP_005649345.1 hypothetical protein -
DV390_RS06485 1308251..1309750 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
DV390_RS06490 1309752..1310693 + 942 WP_011272055.1 1-phosphofructokinase -
DV390_RS06495 1310695..1312365 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T108702 WP_011272058.1 NZ_CP031242:1307278-1307556 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T108702 NZ_CP031242:1307278-1307556 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT108702 WP_011272059.1 NZ_CP031242:1307078-1307269 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT108702 NZ_CP031242:1307078-1307269 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References