Detailed information of TA system TA108701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1108384..1108855
• Replicon: chromosome
• Accession: NZ_CP031242
• Organism: Haemophilus influenzae strain M21460

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: DV390_RS05455
• Protein ID: WP_005654546.1
• Coordinates: 1108384..1108566 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV390_RS05460
• Protein ID: WP_005650837.1
• Coordinates: 1108559..1108855 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV390_RS05450	1105070..1108114	+	3045	WP_162816777.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV390_RS05455	1108384..1108566	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
DV390_RS05460	1108559..1108855	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV390_RS05465	1109039..1110955	+	1917	WP_042594707.1	ABC transporter ATP-binding protein	-
DV390_RS05470	1110965..1111501	+	537	WP_042594704.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV390_RS05475	1111517..1112068	+	552	WP_042594703.1	Sua5/YciO/YrdC/YwlC family protein	-
DV390_RS05480	1112072..1112878	+	807	WP_042594702.1	shikimate dehydrogenase	-
DV390_RS05485	1112890..1113642	+	753	WP_011272149.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T108701 WP_005654546.1 NZ_CP031242:1108384-1108566 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T108701 NZ_CP031242:1108384-1108566 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108701 WP_005650837.1 NZ_CP031242:1108559-1108855 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108701 NZ_CP031242:1108559-1108855 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9