Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 482252..482841 Replicon chromosome
Accession NZ_CP031242
Organism Haemophilus influenzae strain M21460

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag DV390_RS02380 Protein ID WP_005653200.1
Coordinates 482593..482841 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag DV390_RS02375 Protein ID WP_005653201.1
Coordinates 482252..482596 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV390_RS02360 477475..478869 - 1395 WP_042594484.1 sodium-coupled multidrug efflux MATE transporter HmrM -
DV390_RS02365 478913..479527 + 615 WP_005657019.1 riboflavin synthase -
DV390_RS02370 479599..482208 - 2610 WP_042594483.1 aminopeptidase N -
DV390_RS02375 482252..482596 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DV390_RS02380 482593..482841 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
DV390_RS02385 483012..483506 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DV390_RS02390 483576..484664 + 1089 WP_042594482.1 5-(carboxyamino)imidazole ribonucleotide synthase -
DV390_RS02395 484804..485994 + 1191 WP_042594481.1 aspartate/tyrosine/aromatic aminotransferase -
DV390_RS02400 486153..486770 - 618 WP_013525984.1 energy-coupling factor ABC transporter ATP-binding protein -
DV390_RS02405 486772..487404 - 633 WP_042594480.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T108699 WP_005653200.1 NZ_CP031242:c482841-482593 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T108699 NZ_CP031242:c482841-482593 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT108699 WP_005653201.1 NZ_CP031242:c482596-482252 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT108699 NZ_CP031242:c482596-482252 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References