Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1769353..1769984 Replicon chromosome
Accession NZ_CP031241
Organism Haemophilus influenzae strain M17648

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag DV384_RS08760 Protein ID WP_005651560.1
Coordinates 1769353..1769751 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag DV384_RS08765 Protein ID WP_005648011.1
Coordinates 1769751..1769984 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV384_RS08740 1764536..1765654 + 1119 WP_112071379.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
DV384_RS08745 1765655..1766677 + 1023 WP_005655937.1 outer membrane-stress sensor serine endopeptidase DegS -
DV384_RS08750 1766751..1767566 - 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
DV384_RS08755 1767798..1769333 - 1536 WP_114890557.1 L-2,4-diaminobutyrate decarboxylase -
DV384_RS08760 1769353..1769751 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
DV384_RS08765 1769751..1769984 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DV384_RS08770 1770131..1771495 - 1365 WP_114890556.1 diaminobutyrate--2-oxoglutarate transaminase -
DV384_RS08775 1771842..1772012 - 171 WP_005613503.1 50S ribosomal protein L33 -
DV384_RS08780 1772024..1772260 - 237 WP_005542826.1 50S ribosomal protein L28 -
DV384_RS08785 1772474..1773139 - 666 WP_013527272.1 DNA repair protein RadC -
DV384_RS08790 1773303..1774505 + 1203 WP_114890555.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T108697 WP_005651560.1 NZ_CP031241:c1769751-1769353 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T108697 NZ_CP031241:c1769751-1769353 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT108697 WP_005648011.1 NZ_CP031241:c1769984-1769751 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT108697 NZ_CP031241:c1769984-1769751 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References