108695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1243395..1243873 Replicon chromosome
Accession NZ_CP031241
Organism Haemophilus influenzae strain M17648

Toxin (Protein)


Gene name VapD Uniprot ID A0A2S9S1N6
Locus tag DV384_RS06090 Protein ID WP_005691372.1
Coordinates 1243395..1243673 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag DV384_RS06095 Protein ID WP_005649350.1
Coordinates 1243682..1243873 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV384_RS06070 1238586..1240256 - 1671 WP_114934602.1 fructose-specific PTS transporter subunit EIIC -
DV384_RS06075 1240258..1241199 - 942 WP_114934603.1 1-phosphofructokinase -
DV384_RS06080 1241201..1242700 - 1500 WP_114934604.1 fused PTS fructose transporter subunit IIA/HPr protein -
DV384_RS06085 1242772..1243302 - 531 WP_005686915.1 hypothetical protein -
DV384_RS06090 1243395..1243673 - 279 WP_005691372.1 virulence-associated protein VapD Toxin
DV384_RS06095 1243682..1243873 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
DV384_RS06100 1243944..1245242 - 1299 WP_005691371.1 hemolysin family protein -
DV384_RS06105 1245293..1245817 - 525 WP_005652096.1 DUF1523 family protein -
DV384_RS06110 1245844..1246626 - 783 WP_114934605.1 YchF/TatD family DNA exonuclease -
DV384_RS06115 1246681..1247664 - 984 WP_114934606.1 DNA polymerase III subunit delta' -
DV384_RS06120 1247661..1248293 - 633 WP_032826288.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10706.10 Da        Isoelectric Point: 4.9670

>T108695 WP_005691372.1 NZ_CP031241:c1243673-1243395 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGETLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T108695 NZ_CP031241:c1243673-1243395 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGCGAAACCTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTTTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT108695 WP_005649350.1 NZ_CP031241:c1243873-1243682 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT108695 NZ_CP031241:c1243873-1243682 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9S1N6

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References