Detailed information of TA system TA108692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1788704..1789293
• Replicon: chromosome
• Accession: NZ_CP031240
• Organism: Haemophilus haemolyticus strain M19345

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DV427_RS08860
• Protein ID: WP_114892075.1
• Coordinates: 1789045..1789293 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q4QL50
• Locus tag: DV427_RS08855
• Protein ID: WP_005653201.1
• Coordinates: 1788704..1789048 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV427_RS08850	1786041..1788650	-	2610	WP_114892074.1	aminopeptidase N	-
DV427_RS08855	1788704..1789048	-	345	WP_005653201.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DV427_RS08860	1789045..1789293	-	249	WP_114892075.1	type II toxin-antitoxin system HicA family toxin	Toxin
DV427_RS08865	1789464..1789958	+	495	WP_114892076.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DV427_RS08870	1790029..1791117	+	1089	WP_114892077.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DV427_RS08875	1791257..1792447	+	1191	WP_114892078.1	aspartate/tyrosine/aromatic aminotransferase	-
DV427_RS08880	1792494..1792946	-	453	WP_114892079.1	molybdopterin synthase catalytic subunit MoaE	-
DV427_RS08885	1792947..1793192	-	246	WP_114892080.1	molybdopterin synthase sulfur carrier subunit	-
DV427_RS08890	1793194..1793676	-	483	WP_114892192.1	cyclic pyranopterin monophosphate synthase MoaC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-81)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9437.98 Da
• Isoelectric Point: 10.4673

>T108692 WP_114892075.1 NZ_CP031240:c1789293-1789045 [Haemophilus haemolyticus]
MGRIEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Nucleotide

• Length: 249 bp

>T108692 NZ_CP031240:c1789293-1789045 [Haemophilus haemolyticus]
ATGGGACGAATTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13142.04 Da
• Isoelectric Point: 4.8151

>AT108692 WP_005653201.1 NZ_CP031240:c1789048-1788704 [Haemophilus haemolyticus]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Nucleotide

• Length: 345 bp

>AT108692 NZ_CP031240:c1789048-1788704 [Haemophilus haemolyticus]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGTTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTGTTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0M1GMF9